Tamoxifen stroke

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  1. Dеn New Member

    Tamoxifen stroke


    I am 42 years old and have had classical migraines for about twenty years. Fortunately, I usually don't have a headache with them, and they have never been too troublesome. They have never been more frequent than every nine months or so. I have been taking tamoxifen for the last year and am aware that I am at an increased risk for having a stroke caused by blood clots. I wasn't too concerned about this side effect until my migraines became much more frequent, four in the last year, and three in the last four months. Also worrisome is that the aura has started when I have been in the middle of a run, which I do daily, and this is new. I have two grandparents, one on each side of the family who died fairly young, both at 66 years old, of stroke. I am now very concerned about having a stroke, especially in light of the studies that have linked classical migraines and increased stroke risk. Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Use a barrier form of birth control (such as a condom or diaphragm with spermicide) while you are using this medication and for at least 2 months after your treatment ends. Tamoxifen may also be used for purposes not listed in this medication guide. You should not use tamoxifen if you are allergic to it, or if you have a history of blood clots in your veins or your lungs, or if you are also taking a blood thinner such as warfarin (Coumadin). Before using this medicine, tell your doctor if you have liver disease, high triglycerides (a type of fat in the blood), a history of cataract, or a history of stroke or blood clot. Also tell your doctor if you if you are receiving chemotherapy or radiation treatment.

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    Dec 5, 2012. Studies that looked as solid as this week's tamoxifen study assured. the risk of pulmonary embolism, DVT, stroke and endometrial cancer. St. Paul, Minn. – A recent analysis of tamoxifen studies completed since 1980 revealed an increased risk of stroke in women who were randomized to tamoxifen. Abstract—Objective To assess the overall risk of stroke, specifically ischemic stroke, associated with tamoxifen use by performing a meta-analysis of data.

    Please note: This article was published more than one year ago. The facts and conclusions presented may have since changed and may no longer be accurate. Questions about personal health should always be referred to a physician or other health care professional. 20, 2004 (Health Day News) -- Taking tamoxifen to treat breast cancer won't increase your risk of stroke. However, a report on that finding, which appears in the Oct. 20 issue of the Journal of the National Cancer Institute, did conclude that chemotherapy can raise the odds of a brain attack."The bottom line from this study is when we looked at women who had a first stroke after their breast cancer diagnosis, we did not see a relationship between tamoxifen and stroke," said study co-author Ann Geiger, group leader in cancer research at Kaiser Permanente Southern California in Pasadena. Tamoxifen is a drug sometimes called an anti-estrogen because it interferes with estrogen activity that can help breast cancer cells grow. Tamoxifen has been used for more than 20 years as a treatment for breast cancer, and many women who are at high risk for breast cancer use tamoxifen today to try to prevent the disease. Previous studies had shown that tamoxifen could increase a woman's risk of stroke. The breast cancer drug tamoxifen appears to increase a woman’s risk of having a stroke, although the overall risk is small, according to a systematic review of nearly 25 years worth of clinical trials of the drug. Doctors say the finding should not stop breast cancer patients from taking tamoxifen. But it could be a factor for women who are considering the drug to prevent the disease, especially those who are at high risk for stroke. For years, doctors have known that tamoxifen increases the risk of venous thromboembolism, a type of blood clot that often forms in the legs and can migrate to the lungs and other parts of the body. Whether tamoxifen increases the risk of a stroke has been unclear; a couple of studies have found a reduced risk and several found an increased risk. To determine the stroke risk posed by tamoxifen, Duke University researchers pooled findings from nine clinical trials involving about 40,000 breast cancer patients. Over a five-year period, women taking tamoxifen had a 29 percent greater risk of having any type of stroke and an 82 percent greater chance of ischemic stroke, compared with women who received placebos or some other drug.

    Tamoxifen stroke

    Risk of ischemic stroke with tamoxifen treatment for breast cancer a., Analysis of Tamoxifen Studies Reveals Slight Increase of Stroke. - AAN

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  6. Oct 17, 2017. Bushnell, C. D. and Goldstein, L. B. 2004. Risk of ischemic stroke with tamoxifen treatment for breast cancer a meta-analysis. Neurology 63.

    • Frontiers Tamoxifen Use Correlates with Increased Risk of the First..
    • Risk of ischemic stroke with tamoxifen treatment for breast. - Neurology.
    • Tamoxifen Doesn't Increase Stroke Risk - Consumer HealthDay.

    Tamoxifen may cause cancer of the uterus womb, strokes, and blood clots in the lungs. These conditions may be serious or fatal. Tell your doctor if you have ever had a blood clot in the lungs or legs, a stroke, or a heart attack. Feb 18, 2017. Tamoxifen Some studies have found that there is a small but real increase in stroke risk in women who take tamoxifen, probably due to the. Tamoxifen Nolvadex® is a medication in pill form that has been used for more than 25 years to treat breast cancer in women and men. Tamoxifen is one of the most common endocrine therapy drugs. It has been shown to decrease the chance of recurrence in some early-stage breast cancers and to prevent the development of cancer in the opposite breast.

     
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