Because fluoroquinolones, including CIPRO, have been associated with serious adverse reactions (5.1-5.15), reserve CIPRO for use in patients who have no alternative treatment options for the following indications: Although treatment of infections due to this organism in this organ system demonstrated a clinically significant outcome, efficacy was studied in fewer than 10 patients. CIPRO is indicated in adult patients for treatment of typhoid fever (enteric fever) caused by The efficacy of ciprofloxacin in the eradication of the chronic typhoid carrier state has not been demonstrated. CIPRO is indicated in adult patients for treatment of uncomplicated cervical and urethral gonorrhea due to CIPRO is indicated in adults and pediatric patients from birth to 17 years of age for inhalational anthrax (post-exposure) to reduce the incidence or progression of disease following exposure to aerosolized and prophylaxis for plague in adults and pediatric patients from birth to 17 years of age. Efficacy studies of ciprofloxacin could not be conducted in humans with plague for feasibility reasons. Therefore this indication is based on an efficacy study conducted in animals only Because fluoroquinolones, including CIPRO, have been associated with serious adverse reactions [see Warnings and Precautions (5.1-5.15)] and for some patients acute uncomplicated cystitis is self-limiting, reserve CIPRO for treatment of acute uncomplicated cystitis in patients who have no alternative treatment options. CIPRO is indicated in pediatric patients aged one to 17 years of age for treatment of complicated urinary tract infections (c UTI) and pyelonephritis due to . Although effective in clinical trials, CIPRO is not a drug of first choice in the pediatric population due to an increased incidence of adverse reactions compared to controls, including reactions related to joints and/or surrounding tissues To reduce the development of drug-resistant bacteria and maintain the effectiveness of CIPRO and other antibacterial drugs, CIPRO should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Is a registered trademark of Bayer Health Care Pharmaceuticals Inc. This information has been designed as a quick reference. It is intended as a reference source only and not for prescribing or dispensing product. The appropriate approved prescribing information should be consulted. Images viewed herein may appear different than they do when viewing them live because of computer and/or photographic distortion. 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