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  1. Klesch Well-Known Member

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    Cialis vs tadalafil

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  5. Schneider Moderator

    Some corticosteroids such as prednisone and dexamethasone cause euphoria as a side effect especially at the start of treatment, although it diminishes after a few days once your body becomes tolerant to the steroid, and indeed with prolonged treatment at high dose the opposite effect develops and you get depressed and irritable. Is anyone aware of research into the mechanism for this? It seems to be directly mediated through the steroid receptors according to this paper; but I can't find much more information out about it. Seems like another potential target for euphoria-inducing drugs, I wonder if it would be possible to make a drug which acted via this target but lacked the various side effects of corticosteroid drugs, and didn't produce tolerance to the euphoria so quickly. Certainly seems to be quite seperate from the mechanisms of any conventional drugs of abuse, although I bet secondary dopamine release is involved to some extent. Corticosteroids have been reported to work for social anxiety too, hmm reducing anxiety and causing euphoria not bad.. but they are LESS healthy then most recreational drugs but i gues if because of these drugs they find differend routs to cause euphoria that would be interesting Did you see the following article? Prednisone tapering schedule from 50 mg, Prednisone 20 mg. Corticosteroid euphoria Archive - Bluelight Prednisone - MultiCare Health System
     
  6. almov XenForo Moderator

    Orapred ODT prednisolone sodium phosphate dose, indications. Oral dosage prednisolone or prednisolone sodium phosphate. The Global Initiative for Asthma guidelines recommend weight-based dosing 1 mg/kg/day;.

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