Because this is a personal blog, I hope you will indulge me for a moment as I make what is, to me anyway, a very important announcement about my life. I am purchasing nothing but baseball ties from here on in. They were the sort of people who belonged to country clubs and drank champagne from crystal tulip glasses and clicked croquet balls through those hoopy things stuck into the ground and they all had spouses named “Lovey” like Thurston Howell III. It’s red and has a bunch of little sketches of the proper way to hold the baseball when throwing different pitches. It’s one that features the Norman Rockwell painting of the umpires deciding to call the game because of rain. From this day forward, I intend to only wear baseball ties. I’m sure this has happened to you — for years, I have thought about making this transition to an all baseball tie wardrobe, but the time was never quite right. On those rare days when my father wore a tie, you knew something big and vital was about to happen — someone was about get married, someone had just passed away, the factory was having the big Christmas party at the owner’s house. There’s the knuckleball grip, the slider grip, the palmball grip (palmball! For years, I wore real ties — “real” meaning “ties that do not necessarily have baseballs on them” — and it was fine. It’s actually called “Game Called Because of Rain.” I had to get that tie, it was way cool. Yes, sure, first thing you will say is: “Wait, you’re going to wear a BASEBALL TIE to a somber event like a funeral or the dinner when you accept the National Book Award for your soon to be finished book on Harry Houdini? The hope was that I would become a doctor, naturally. The everything-must-go-store-closing settlement was accountant. In my mind, men who wore ties to work, wow, they were rich and powerful. and I was in the gift shop, and I saw this awesome baseball tie. I wore a different baseball tie every day until I ran out (I think I have 11 of them now) and then started over. I began this all-baseball-tie process last October during the baseball playoffs. There was a clear, “We sacrifice so that you will have a better life” theme throughout my childhood. I didn’t know many men who wore ties to work; they mostly did not live in our neighborhood. Back to how this happened: Last year I was at the Baseball Hall of Fame for this incredibly cool project that I can’t wait to tell you about … So during the playoffs last year, I made the switch. I mean, people noticed individual ties — partiparticularly Norman Rockwell one which seems to be the most beloved of the group so far — but nobody noticed that I was wearing only baseball ties. Also, I am in the market for baseball ties that will fit all occasions. My parents are immigrants who came to America just three years before I was born. My mother stayed at home (though she later went back to school and became a computer programmer). It’s hard to describe the power of suits and ties in my childhood imagination. Seriously, who am I trying to impress at this point in my life? What a great group, and before it began I went to see the delightful Andrea Thome, Jim’s wife, who my wife and I got to know many years ago. I work in a profession where you really don’t have to wear a tie, and I do anyway. I have theorized — because, honestly, it’s just a theory — that the reason I wear a jacket and tie is that my parents always hoped that I would have a jacket-and-tie kind of job. well, just today, I went to the Hall of Fame press conference for Jim Thome, Chipper Jones, Vladimir Guerrero and Trevor Hoffman. I will readily admit that my midlife crisis does not have the same energy as the convertible sports-car midlife crisis, but that’s OK. I am like the opposite of the cool executive and creative types you read about who brag about how they love their job precisely because they don’t have to wear a tie. I think back to my younger self, the kid who wanted to make a success of his life but had neither the will nor the brains to do it the conventional way, and I would love to tell him that I have a job where I wear jackets and ties. “Cool,” he would say or whatever the word was at that time. Mild/moderate: 500 mg PO q12hr or 400 mg IV q12hr for 7-14 days Severe/complicated: 750 mg PO q12hr or 400 mg IV q8hr for 7-14 days Limitations-of-use: Reserve fluoroquinolones for patients who do not have other available treatment options for acute bacterial exacerbation of chronic bronchitis Acute uncomplicated: Immediate-release, 250 mg PO q12hr for 3 days; extended-release, 500 mg PO q24hr for 3 days Mild/moderate: 250 mg PO q12hr or 200 mg IV q12hr for 7-14 days Severe/complicated: 500 mg PO q12hr or 400 mg IV q12hr for 7-14 days Limitations-of-use: Reserve fluoroquinolones for patients who do not have other available treatment options for uncomplicated urinary tract infections Dry powder for inhalation: Orphan designation for patients with NCFB who suffer from frequent severe acute pulmonary bacterial exacerbations which lead to further inflammation, airway, and lung parenchyma damage Indication for treatment and prophylaxis of plague due to Yersinia pestis in pediatric patients from birth to 17 years of age 15 mg/kg PO q8-12hr x10-21 days; not to exceed 500 mg/dose, OR 10 mg/kg IV q8-12hr x 10-21 days; not to exceed 400 mg/dose Postexposure therapy IV: 10 mg/kg q12hr for 60 days; individual dose not to exceed 400 mg PO: 15 mg/kg q12hr for 60 days; individual dose not to exceed 500 mg Change antibiotic to amoxicillin as soon as penicillin susceptibility confirmed Nausea (3%) Abdominal pain (2%) Diarrhea (2% adults; 5% children) Increased aminotransferase levels (2%) Vomiting (1% adults; 5% children) Headache (1%) Increased serum creatinine (1%) Rash (2%) Restlessness (1%) Acidosis Allergic reaction Angina pectoris Anorexia Arthralgia Ataxia Back pain Bad taste Blurred vision Breast pain Bronchospasm Diplopia Dizziness Drowsiness Dysphagia Dyspnea Flushing Foot pain Hallucinations Hiccups Hypertension Hypotension Insomnia Irritability Joint stiffness Lethargy Migraine Nephritis Nightmares Oral candidiasis Palpitation Photosensitivity Polyuria Syncope Tachycardia Tinnitus Tremor Urinary retention Vaginitis Acute generalized exanthematous pustulosis (AGEP), erythema multiforme, exfoliative dermatitis, fixed eruption, photosensitivity/phototoxicity reaction Agitation, confusion, delirium Agranulocytosis, albuminuria, serum cholesterol and TG elevations, blood glucose disturbances, hemolytic anemia, marrow depression (life threatening), pancytopenia (life threatening or fatal outcome), potassium elevation (serum) Anaphylactic reactions (including life-threatening anaphylactic shock), serum sickness like reaction, Stevens-Johnson syndrome Anosmia, hypesthesia Constipation, dyspepsia, dysphagia, flatulence, hepatic failure (including fatal cases), hepatic necrosis, jaundice, pancreatitis Hypertonia, hypotension (postural), increased INR (in patients treated with Vitamin K antagonists), QT prolongation, torsade de pointes, ventricular arrhythmia Methemoglobinemia Myasthenia, exacerbation of myasthenia gravis, myoclonus, nystagmus, peripheral neuropathy that may be irreversible, phenytoin alteration (serum), polyneuropathy, psychosis Myalgia, tendinitis, tendon rupture, toxic epidermal necrolysis (Lyell’s Syndrome), twitching Infections: Candiduria, vaginal candidiasis, moniliasis (oral, gastrointestinal, vaginal), pseudomembranous colitis Renal calculi Vasculitis Because the risk of these serious side effects generally outweighs the benefits for patients with acute bacterial sinusitis, acute exacerbation of chronic bronchitis, and uncomplicated UTIs, that fluoroquinolones should be reserved for use in patients with these conditions who have no alternative treatment options Use in pregnancy, though generally contraindicated for all quinolones, is allowed for life-threatening situations; limited data from use of ciprofloxacin in pregnancy show no higher rate of birth defects than background Do not use oral suspension in nasogastric tube; to prepare, add microcapsules to diluent Commonly seen adverse reactions include tendinitis, tendon rupture, arthralgia, myalgia, peripheral neuropathy, and central nervous system effects (hallucinations, anxiety, depression, insomnia, severe headaches, and confusion); these reactions can occur within hours to weeks after starting therapy, including in patients of any age or without pre-existing risk factors; discontinue therapy immediately at first signs or symptoms of any serious adverse reaction; in addition, avoid use of fluoroquinolones, in patients who have experienced any serious adverse reactions associated with fluoroquinolones (see Black Box Warnings) Peripheral neuropathy: sensory or sensorimotor axonal polyneuropathy affecting small and/or large axons resulting in paresthesias, hypoesthesias, dysesthesias, and weakness reported; peripheral neuropathy may occur rapidly after initiating and may potentially become permanent In prolonged therapy, perform periodic evaluations of organ system functions (eg, renal, hepatic, hematopoietic); adjust dose in renal impairment; superinfections may occur with prolonged or repeated antibiotic therapy; discontinue use immediately if signs and symptoms of hepatitis occur Not first drug of choice in pediatrics (except in anthrax), because of increased incidence of adverse events in comparison with control subjects, including arthropathy; no data exist on dosing for pediatric patients with renal impairment (ie, Cr Cl Distributed widely throughout body; tissue concentrations often exceed serum concentrations, especially in kidneys, gallbladder, liver, lungs, gynecologic tissue, and prostatic tissue; cerebrospinal fluid (CSF) concentration is 10% in noninflamed meninges and 14-37% in inflamed meninges; crosses placenta; enters breast milk Protein bound: 20-40% Vd: 2.1-2.7 L/kg Additive: Aminophylline, amoxicillin, amoxicillin-clavulanate, amphotericin, ampicillin-sulbactam, ceftazidime, cefuroxime, clindamycin, floxacillin, heparin, piperacillin, sodium bicarbonate, ticarcillin Y-site: Aminophylline, ampicillin-sulbactam, azithromycin, cefepime, dexamethasone sodium phosphate, furosemide, heparin, hydrocortisone sodium succinate, magnesium sulfate(? ), methylprednisolone sodium succinate, phenytoin, potassium phosphates, propofol, sodium bicarbonate(? ), sodium phosphates, total parenteral nutrition formulations, warfarin Solution: Compatible with most IV fluids Additive: Amikacin, aztreonam, dobutamine, dopamine, fluconazole, gentamicin, lidocaine, linezolid, metronidazole (ready-to-use form is compatible; hydrochloride form in vial is incompatible), midazolam, potassium chloride, tobramycin Y-site: Amiodarone, calcium gluconate, clarithromycin, digoxin, diphenhydramine, dobutamine, dopamine, linezolid, lorazepam, midazolam, promethazine, quinupristin/dalfopristin, tacrolimus The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Amoxicillin side effects in adults Tadalafil injection A study11 comparing a three-day course of ciprofloxacin Cipro 100 mg twice. newest formulation of extended-release ciprofloxacin 500 mg daily. Management of Uncomplicated Urinary Tract. Cipro official prescribing information for healthcare professionals. Includes indications, dosage, adverse reactions, pharmacology and more. Detailed dosage guidelines and administration information for Cipro ciprofloxacin hydrochloride. Includes dose adjustments, warnings and precautions. The determination of dosage and duration for any particular patient must take into consideration the severity and nature of the infection, the susceptibility of the causative microorganism, the integrity of the patient’s host-defense mechanisms, and the status of renal and hepatic function. CIPRO Tablets or Oral Suspension may be administered to adult patients when clinically indicated at the discretion of the physician. Administer CIPRO for Oral Suspension using the co-packaged graduated spoon Dosing and initial route of therapy (that is, IV or oral) for c UTI or pyelonephritis should be determined by the severity of the infection. CIPRO should be administered as described in Table 3. Administer CIPRO for Oral Suspension using the co-packaged graduated spoon Ciprofloxacin is eliminated primarily by renal excretion; however, the drug is also metabolized and partially cleared through the biliary system of the liver and through the intestine. These alternative pathways of drug elimination appear to compensate for the reduced renal excretion in patients with renal impairment. Nonetheless, some modification of dosage is recommended, particularly for patients with severe renal dysfunction. Quinolone antibiotics (including ciprofloxacin) may cause serious and possibly permanent tendon damage (such as tendonitis, tendon rupture), nerve problems in the arms and legs (peripheral neuropathy), and nervous system problems. Get medical help right away if you have any of the following symptoms: pain/numbness/burning/tingling/weakness in your arms/hands/legs/feet, changes in how you sense touch/pain/temperature/vibration/body position, severe/lasting headache, vision changes, shaking (tremors), seizures, mental/mood changes (such as agitation, anxiety, confusion, hallucinations, depression, rare thoughts of suicide). Tendon damage may occur during or after treatment with this medication. Stop exercising, rest, and get medical help right away if you develop joint/muscle/tendon pain or swelling. Your risk for tendon problems is greater if you are over 60 years of age, if you are taking corticosteroids (such as prednisone), or if you have a kidney, heart, or lung transplant. 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