This is a list of compounds that are in the BPP dataset. Indication: Treatment of hypertension, alone or in combination with other antihypertensive agents. Dosing (Adults): Hypertension: Initial: 150 mg once daily; may increase to 300 mg once daily (maximum: 300 mg/day). Note: Prior to initiation, correct hypovolemia and/or closely monitor volume status in patients on concurrent diuretics during treatment initiation. 2 mg/d L (men)]: Use caution; not studied in severe renal impairment. Administration: Administer at the same time daily; may take with or without a meal, but consistent administration with regards to meals is recommended. Supplied: Tablet: 150 mg, 300 mg Endothelin receptor antagonist. did not appear to confer additional benefit sufficient to offset the increased risk of liver injury. Adult (usual) Pulmonary arterial hypertension (PAH): initial, 62.5 mg po bid x 4 weeks. Monitoring: monitor liver function before and during therapy. 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