Tamoxifen in infertility

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    Tamoxifen in infertility


    This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. 7, 2003 -- There's new hope for young women who must undergo breast cancer chemotherapy and will likely lose their fertility because of the drugs' side effects. Researchers at Cornell University have found that the drug tamoxifen, used to treat and prevent breast cancer, also stimulates the ovaries' ability to produce eggs. In a study of 12 breast cancer patients, doctors found that by giving women tamoxifen, more eggs than normal could be retrieved, says Kutluk Oktay, MD, assistant professor of reproductive endocrinology at the Weill Medical College of Cornell University in New York. Every patient in his study had one or more embryos that were either immediately transferred or frozen for later attempts at pregnancy. Now two years' later, two pregnancies have occurred -- one involving a set of twins, he tells Web MD. Oktay's paper appears in the January edition of the European medical journal Human Reproduction. In order to use Medscape, your browser must be set to accept cookies delivered by the Medscape site. Medscape uses cookies to customize the site based on the information we collect at registration. The cookies contain no personally identifiable information and have no effect once you leave the Medscape site.

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    Worldwide, polycystic ovarian syndrome PCOS is the most common cause of anovulatory infertility accounting for 20–25% of all cases of. Clomiphene citrate, ovulation induction, pregnancy, tamoxifen. after treatment with tamoxifen or clomiphene for isolated anovulatory infertility. US fertility experts have discovered a potential new role for the wonder drug tamoxifen - helping breast cancer patients to have babies by IVF.

    Suzanne Elvidge has been a freelance writer since 2006, and has spent the last 25 years working in science journalism, publishing, and communications. She writes about pharmaceuticals, consumer healthcare and medicine, and the healthcare, pharmaceutical and biotechnology industries. She has written for a variety of magazines and journals, including Nature Biotechnology, Life Science Leader, New Scientist, Start-Up and Chemistry & Industry, and has authored a number of industry reports and ebooks. She also blogs on a range of topics from PCR, through bioinformatics and big data, to interesting and quirky science facts, books and food, and tweets as @suzannewriter. Tamoxifen has had a major impact on reducing the risk of breast cancer recurrences, but many younger women are either not starting treatment or are discontinuing it early. This could be caused by worries about fertility, according to research published in on 24 August 2015. To understand more about the reasons behind the low levels of uptake, researchers looked at the electronic medical records of young women with hormone receptor-positive breast cancer treated at the Northwestern Memorial Hospital’s Lynn Sage Comprehensive Breast Center in Chicago, Illinois. BACKGROUND: Both selective estrogen receptor modulators, tamoxifen and clomiphene have been used for ovulation induction for patients with anovulatory infertility. This meta-analysis sought to compare the effectiveness of tamoxifen to clomiphene for the induction of ovulation and achievement of pregnancy. METHODS: We searched MEDLINE, BIOSIS, Pre MEDLINE, CINAHL, International Pharmaceutical Abstracts, DDSR, ACP Journal Club, DARE and CCTR, along with reference lists and national experts. Inclusion criteria were prospective clinical trials, which compared tamoxifen and clomiphene for ovulation induction in infertile couples with isolated anovulatory infertility. Main outcome measures were ovulation rate and clinical pregnancy rate. Pooled odds ratios were obtained using random effects meta-analysis. After pooling all the trials, the use of tamoxifen or clomiphene citrate resulted in similar ovulation rates [odds ratio (OR) 0.755, 95% confidence interval (CI) 0.513–1.111]. There was no benefit of tamoxifen over clomiphene citrate in achievement of pregnancy per cycle (OR 1.056, 95% CI 0.583–1.912) or per ovulatory cycle (OR 1.162, 95% CI 0.632–2.134).

    Tamoxifen in infertility

    How does tamoxifen assist ovulation?, Comparison of tamoxifen and clomiphene citrate for ovulation.

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  4. Oct 19, 2017. Information about taking tamoxifen for breast cancer or infertility treatment, including how does tamoxifen work, tamoxifen side effects.

    • Tamoxifen citrate uses, action, side effects and dosage information.
    • New role for tamoxifen as fertility drug for breast cancer patients..
    • Ovulation Induction Treatment Tennessee Reproductive Medicine.

    Why is the breast cancer drug, Tamoxifen, prescribed for infertility? Apr 21, 2005. Inclusion criteria were prospective clinical trials, which compared tamoxifen and clomiphene for ovulation induction in infertile couples with. Jun 24, 2015. PCOS, Drug Clomiphene citrate Drug Tamoxifen Placebo Drug. Interval of earlier treatment with any of the fertility drugs of less than 6.

     
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