Tamoxifen or letrozole

Discussion in 'Online Pharmacies Canada' started by vaniya, 24-Dec-2019.

  1. HuttyLeee Well-Known Member

    Tamoxifen or letrozole


    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Hormone therapy using letrozole may fight breast cancer by reducing the production of estrogen. Antonov J, Popovici V, Delorenzi M, Wirapati P, Baltzer A, Oberli A, Thürlimann B, Giobbie-Hurder A, Viale G, Altermatt HJ, Aebi S, Jaggi R. Cognitive function in postmenopausal women receiving adjuvant letrozole or tamoxifen for breast cancer in the BIG 1-98 randomized trial. Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer. Listing a study does not mean it has been evaluated by the U. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen by the tumor cells. Molecular risk assessment of BIG 1-98 participants by expression profiling using RNA from archival tissue. RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Phillips KA, Ribi K, Sun Z, Stephens A, Thompson A, Harvey V, Thürlimann B, Cardoso F, Pagani O, Coates AS, Goldhirsch A, Price KN, Gelber RD, Bernhard J. BIG 1-98 Collaborative Group, Mouridsen H, Giobbie-Hurder A, Goldhirsch A, Thürlimann B, Paridaens R, Smith I, Mauriac L, Forbes J, Price KN, Regan MM, Gelber RD, Coates AS. Design, conduct, and analyses of Breast International Group (BIG) 1-98: a randomized, double-blind, phase-III study comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive, early breast cancer. Bone Quality Test (BQT) scores of fingernails in postmenopausal patients treated with adjuvant letrozole or tamoxifen for early breast cancer. Letrozole compared with tamoxifen for elderly patients with endocrine-responsive early breast cancer: the BIG 1-98 trial. If is not yet known which treatment regimen is most effective for breast cancer. Zaman K, Thürlimann B, Huober J, Schönenberger A, Pagani O, Lüthi J, Simcock M, Giobbie-Hurder A, Berthod G, Genton C, Brauchli P, Aebi S; Swiss Group for Clinical Cancer Research (SAKK). PURPOSE: Randomized double-blind phase III trial to compare the effectiveness of letrozole with that of tamoxifen in treating postmenopausal women who have breast cancer that has been surgically removed. Viale G, Regan MM, Dell'Orto P, Mastropasqua MG, Maiorano E, Rasmussen BB, Mac Grogan G, Forbes JF, Paridaens RJ, Colleoni M, Láng I, Thürlimann B, Mouridsen H, Mauriac L, Gelber RD, Price KN, Goldhirsch A, Gusterson BA, Coates AS; BIG 1-98 Collaborative and International Breast Cancer Study Groups. Bone mineral density in breast cancer patients treated with adjuvant letrozole, tamoxifen, or sequences of letrozole and tamoxifen in the BIG 1-98 study (SAKK 21/07). OUTLINE: This is a randomized, double-blind, multicenter study. Which patients benefit most from adjuvant aromatase inhibitors? Patients are stratified according to adjuvant chemotherapy (prior therapy vs no prior or concurrent therapy vs concurrent therapy), prior surgery (modified radical mastectomy vs a lesser surgical procedure), and participating center. Regan MM, Price KN, Giobbie-Hurder A, Thürlimann B, Gelber RD; International Breast Cancer Study Group and BIG 1-98 Collaborative Group. Results using a composite measure of prognostic risk in the BIG 1-98 randomized trial. The data show that letrozole, 2.5 mg once daily, is as effective in older, postmenopausal women as it is in younger postmenopausal women with advanced breast cancer. In addition, letrozole was more effective than tamoxifen in both younger and older patients. Presently, 48% of breast cancer cases occur in elderly women (aged 65 years and older) [1], and it is the most common cause of cancer death in women of that age group [2]. Demographic changes in the growing age segment of our population are dramatic: with the aging of the general population, the association between cancer and aging has become more evident and paramount as a pandemic public health concern. As such, formidable increases in the incidence and prevalence of breast cancer can be expected in the coming decades if the older population continues to expand at the present rate [1]. Eighty percent of breast tumors occurring in women aged 70 and older are rich in hormone receptors, while the remaining 20% of women have aggressive tumors that have few hormone receptors [3, 4]. Knowledge of the steroid receptor content of human breast cancer is important for deciding the proper treatment for advanced breast cancer. Endocrine therapy is the established treatment in women with hormone-sensitive tumors, as manifested by positive receptor status, a long disease-free interval, and primarily soft tissue disease.

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    Original Article from The New England Journal of Medicine — A Comparison of Letrozole and Tamoxifen in Postmenopausal Women with Early Breast Cancer. Metabolism of letrozole is partly mediated via CYP2A6 and CYP3A4. Cimetidine, a weak, unspecific inhibitor of CYP450 enzymes, did not affect the plasma concentrations of letrozole. Letrozole is approved by the United States Food and Drug Administration FDA for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women.

    ATLANTA—Postmenopausal women with breast cancer who switch from tamoxifen (Nolvadex) to letrozole (Femara) have a dramatically reduced risk of recurrence and distant metastasis, and they live longer, as evidenced by new data presented at the American Society of Clinical Oncology annual meeting. An updated analysis of the landmark MA-17 trial showed that extended adjuvant use of letrozole, even after years without anticancer therapy, provided significant benefit for 2 populations at high risk of recurrence-women whose cancer has already spread to the lymph nodes at diagnosis (node positive), and women who received chemotherapy after surgery. In this phase 3, double-blind, multicenter trial, 5187 postmenopausal women with early breast cancer who were free of disease after 5 years of tamoxifen therapy were randomly assigned to receive 5 years of letrozole treatment or placebo. The trial was unblinded when the first interim analysis in 2003 showed letrozole lowered the risk of recurrence by 42% compared with placebo. Of the 2268 participants originally assigned to placebo who were then offered letrozole, 1655 women elected to switch to letrozole, while 613 chose not to pursue further treatment. Women who used letrozole for 5 years after tamoxifen significantly improved in all end points. After blinding, a numerical (but not significant) trend was seen toward more clinical fractures in the letrozole-treated patients compared with placebo recipients. Many postmenopausal women take hormonal therapy medicine – either an aromatase inhibitor or tamoxifen – after breast cancer surgery and other treatments for hormone-receptor-positive, early-stage breast cancer. Hormonal therapy medicine can reduce the risk of the cancer coming back (recurrence). A new analysis of results from the BIG 1-98 trial found that the aromatase inhibitor Femara (chemical name: letrozole) improved both disease-free survival (living without the cancer growing) and overall survival (living whether or not the cancer grew) compared to tamoxifen in postmenopausal women diagnosed with estrogen-receptor-positive, HER2-negative breast cancer. The benefits of Femara over tamoxifen were most notable in treating lobular breast cancer compared to ductal breast cancer. Femara was also better at treating luminal B breast cancers with a high level of the protein Ki-67, which helps breast cancer cells grow. The study, "Relative effectiveness of letrozole compared with tamoxifen for patients with lobular carcinoma in the BIG 1-98 trial," was presented at the 2012 San Antonio Breast Cancer Symposium. Lobular breast cancer is breast cancer that begins in the milk-producing lobules, which empty out into the milk ducts that carry milk to the nipple.

    Tamoxifen or letrozole

    Switching From Tamoxifen to Letrozole Improves Breast Cancer Survival, Femara - Summary of Product Characteristics

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  5. Discover FEMARA® letrozole, an approved treatment from Novartis Oncology for HR+ breast cancer in postmenopausal women. Learn about FEMARA® side effects & see recommended FEMARA

    • FEMARA® letrozole 1L Treatment for HR+.
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    Dec 2, 2011. In addition, 5 years of sequential treatment—either 2 years of letrozole followed by 3 years of tamoxifen or 2 years of tamoxifen followed by 3. Nine hundred seven patients with advanced breast cancer were randomly assigned to receive 2.5 mg letrozole n = 453 or 20 mg tamoxifen n = 454 once. Vad Letrozole Sandoz är och hur det verkar. Letrozole Sandoz innehåller en aktiv substans som heter letrozol. Det tillhör en grupp av läkemedel som kallas aromatashämmare.

     
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    COMPATIBLE: Drug which has been taken by a large number of breastfeeding mothers without any observed increase in adverse effects in the infant. Controlled studies in breastfeeding women fail to demonstrate a risk to the infant and the possibility of harm to the breastfeeding infant is remote; or the product is not orally bioavailable in an infant. PROBABLY COMPATIBLE: Drug which has been studied in a limited number of breastfeeding women without an increase in adverse effects in the infant; And/or, the evidence of a demonstrated risk which is likely to follow use of this medication in a breastfeeding woman is remote. There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible, or controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant. (New medications that have absolutely no published data are automatically categorized in this category, regardless of how safe they may be.)POSSIBLY HAZARDOUS: There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). Zoloft During Pregnancy and Breastfeeding Sertraline and Breastfeeding Review and Meta-Analysis - NCBI - NIH Zoloft and Breastfeeding - New Kids Center
     
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