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Vaginal cream, USP, 0.01% at the time the prescription is filled by the pharmacist and. coupon, rebate, free trial, or similar offer for the specified prescription. Estrace is medication to reduce menopause symptoms for women. This Estrace coupon gets a better price when ordering medication online from Canada Drugs. Estrogens, either used alone or with another hormone (progestin), have rarely caused very serious side effects. Discuss the risks and benefits of hormone treatment with your doctor. Estrogens should not be used to prevent heart disease or dementia. Estrogens can increase the risk of cancer of the uterus (endometrial cancer). Taking a progestin as directed by your doctor can help decrease this risk. Tell your doctor right away if you have any unusual vaginal bleeding. In postmenopausal women, estrogens can increase the risk of cancer of the ovaries, stroke, dementia, and serious blood clots in the legs. Wash your hands before and after using the medicine. 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