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    Links to other sites are provided as a convenience to the viewer. Pfizer accepts no responsibility for the content of linked sites. This website is neither owned nor controlled by Pfizer. Pfizer does not endorse and is not responsible for the content or services of this site. Continue You are now leaving to enter a website neither owned nor operated by Pfizer. Links to all outside sites are provided as a resource to our visitors and do not imply an endorsement or recommendation of a particular physician by Pfizer, nor an endorsement of any Pfizer product by a telehealth provider or any physician. Pfizer accepts no responsibility or liability for the content or services of other websites. The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart.

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    The little blue pill may not have ever been if not for one dutiful nurse. Viagra, Pfizer’s blockbuster erectile dysfunction drug hit the market in 1998. In 20 years, it’s become ubiquitous: 62 million men all over the world have bought the drug, according to a Pfizer spokesperson. The US military shells out $41.6 million per year for it, and from 2012 onward, the US, Mexico, and Canada spent about $1.4 billion on it annually (although those numbers are projected to fall in the coming years when Pfizer’s patent on the drug expires in 2020). Despite the drug’s popularity today, the researchers who discovered it weren’t even looking for it. Sildenafil, the active ingredient in Viagra, was originally developed to treat cardiovascular problems. It was meant to dilate the heart’s blood vessels by blocking a particular protein called PDE-5. Viagra (sildenafil) and Levitra (vardenafil) are prescription medications used to treat erectile dysfunction and pulmonary arterial hypertension. Viagra was introduced by Pfizer Pharmaceuticals in March 1998 as a treatment for pulmonary arterial hypertension. The clinical trials revealed that the active ingredient — generically known as sildenafil citrate — also relaxed the muscle tissues in the penis, allowing for increased blood flow. Levitra, introduced in 2003 by Bayer Pharmaceuticals and marketed by Glaxo Smith Kline to treat erectile dysfunction, works similarly. In appearance, Viagra tablets are blue, rounded diamonds that are available in 25 mg, 50 mg, and 100 mg doses. Levitra has orange-colored tablets in 2.5 mg, 5 mg, 10 mg, and 20 mg doses. It is recommended that both medications be taken 30 to 60 minutes before sexual activity is intended.

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