Apo-Simvastatin (CA), Co Simvastatin (CA), Dom-Simvastatin (CA), Gen-Simvastatin (CA), Novo-Simvastatin (CA), Nu-Simvastatin (CA), PHL-Simvastatin (CA), PMS-Simvastatin (CA), Ranzolont (UK), Ratio-Simvastin (CA), Riva-Simvastatin (CA), Sandoz Simvastatin (CA), Simvador (UK), Zocor Adjunct to diet to reduce risk of coronary heart disease (CHD) deaths, cardiovascular events, and hyperlipidemia Adults: Initially, 10 to 20 mg P. Patients unable to achieve their LDL-C goal utilizing 40-mg dose should not be titrated to 80-mg dose, but should be placed on alternative LDL-C-lowering treatment that provides greater LDL-C lowering effects. Heterozygous familial hypercholesterolemia after failure of an adequate trial of diet therapy Adolescent boys and postmenarchal girls ages 10 to 17: Initially, 10 mg P. CNS: headache, asthenia GI: nausea, vomiting, diarrhea, constipation, abdominal pain or cramps, flatulence, dyspepsia Musculoskeletal: myalgia, rhabdomyolysis Respiratory: upper respiratory infection Drug-drug. For patients at high risk for a CHD event due to existing CHD, diabetes, peripheral vessel disease, or history of stroke or other cerebrovascular disease, initial dosage is 40 mg/day. Restrict use of 80-mg dose to patients who have been taking simvastatin 80 mg long term (for example, for 12 months or more) without evidence of muscle toxicity. Range is 10 to 40 mg/day; maximum dose is 40 mg/day. • Hypersensitivity to drug or its components • Active hepatic disease or unexplained persistent serum transaminase elevations • Concurrent use of cyclosporine, danazol, gemfibrozil, or strong CYP3A4 inhibitors • Women who are pregnant or may become pregnant • Breastfeeding patients Use cautiously in: • severe renal impairment; severe acute infection; hypotension; severe metabolic, endocrine, or electrolyte problems; uncontrolled seizures; visual disturbances; myopathy; major surgery; trauma; alcoholism • history of hepatic disease, liver enzyme abnormalities • concurrent use of amiodarone, amlodipine, colchicine, digoxin, diltiazem, and lipid-modifying dosages (1 g/day or more) of niacincontaining products, other fibrates, ranolazine, verapamil, or warfarin • concurrent use of simvastatin in dosages exceeding 20 mg/day with lipid-modifying dosages (1 g/day or more) of niacin-containing products in Chinese patients (avoid use) • large quantities of grapefruit juice (avoid use) • elderly patients • children younger than age 10 (safety not established). Adjunct to other lipid-lowering treatments (such as LDL apheresis) or if such treatments are unavailable for patients with homozygous familial hypercholesterolemia Adults: 40 mg/day P. Amiodarone, calcium channel blockers (such as amlodipine, diltiazem, verapamil), colchicine, other lipid-lowering drugs (such as fibrates or lipid-modifying doses of niacin-containing products), ranolazine, voriconazole: increased risk of myopathy including rhabdomyolysis Cyclosporine, danazol, diltiazem, gemfibrozil, nefazodone, strong CYP3A4 inhibitors (clarithromycin, erythromycin, HIV protease inhibitors, itraconazole, ketoconazole, posaconazole, telithromycin): increased risk of severe myopathy or rhabdomyolysis Digoxin: slightly increased digoxin blood level Warfarin: modestly increased anticoagulant effects Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase: increased levels Drug-food. Grapefruit juice (more than 1 qt daily): increased drug blood level, greater risk of adverse reactions Drug-behaviors. Alcohol use: increased risk of hepatotoxicity Watch closely for myositis and other adverse musculoskeletal reactions. • Monitor liver function tests, CBC, and lipid levels. • In patients receiving warfarin concurrently, closely monitor prothrombin time and International Normalized Ratio. In the Scandinavian Simvastatin Survival Study (a placebo-controlled, randomized clinical trial of five years' duration), simvastatin reduced overall mortality in people with existing cardiovascular disease and high LDL cholesterol by 30% and reduced cardiovascular mortality by 42%. The risks of heart attack, stroke, or needing a coronary revascularization procedure were reduced by 37%, 28%, and 37%, respectively. The Heart Protection Study evaluated the effects of simvastatin in people with risk factors including existing cardiovascular disease, diabetes, or stroke, but having relatively low LDL cholesterol. In this trial, which lasted 5.4 years, overall mortality was reduced by 13% and cardiovascular mortality was reduced by 18%. People receiving simvastatin experienced 38% fewer nonfatal heart attacks and 25% fewer strokes. Results from one trial showed participants assigned to simvastatin had lower odds (0.51 OR) of having AMD progression at three years compared to those assigned to placebo, though the results were not significant. A type of DNA variant known as a single nucleotide polymorphism (SNP) may help predict individuals prone to developing myopathy when taking simvastatin; a study ultimately including 32,000 patients concluded the carriers of one or two risk alleles of a particular SNP, rs4149056, On March 19, 2010, the FDA issued another statement regarding simvastatin, saying it increases the risk of muscle injury (myopathy) when taken at high doses or at lower doses in combination with other drugs. Viagra gel australia Prednisolone acetate 1 Zocor is a common brand name for the medicine simvastatin. It is in a class of medications known as statin drugs that are used to lower the levels of badHowever, like other medicines of this type, the list of Zocor side effects is long, and includes some very serious although rare adverse effects. ZOCOR should be used as an adjunct to other lipid-lowering treatments e.g. If short-term treatment with strong CYP3A4 inhibitors is unavoidable, therapy. Meaning of simvastatin medical term. What does simvastatin mean. in the treatment of hypercholesterolemia and other forms of dyslipidemia and to lower the. Zocor is a common brand name for the medicine simvastatin. It is in a class of medications known as statin drugs that are used to lower the levels of bad cholesterol in the blood. They produce their results by inhibiting the amount of cholesterol that is produced in the liver. These high cholesterol medications are some of the most abundantly prescribed drugs in the United States, with nearly twenty million people using statin drugs regularly to control their cholesterol. However, like other medicines of this type, the list of Zocor side effects is long, and includes some very serious although rare adverse effects. For instance, Zocor is in a class of statins that are fermentation derived. This may explain why as many as one quarter of users discontinue these types of cholesterol medications in the first six months of therapy. Conversely, other popular medications like the likely best known leader, Lipitor, are derived via synthetic means. However, while it may seem that Zocor has a leg up on Lipitor in terms of manufacture with one process sounding more natural or desirable than the other, this phraseology has little to do with production, and both medications share a great majority of adverse reactions in those affected by them. Simvastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs known as "statins." It works by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks. In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, losing weight if overweight, and stopping smoking. Take this medication by mouth as directed by your doctor, usually once daily in the evening. If you are using the tablet form of this medication, you may take this medication with or without food. If you are using the liquid form of this medication, take this medication on an empty stomach. Shake the bottle well for at least 20 seconds before each dose. Other name for zocor Zocor is used for lowering high cholesterol and, Zocor Simvastatin Uses, Side Effects, Drug Interactions, Dosage. Order xenicalWhere to buy flagyl over the counterPropranolol 40 mg side effectsCialis 2.5Fluconazole mode of action Catad_pgroup Статины и другие гиполипидемические средства. Зокор Форте - официальная инструкция по применению. ФАРМАКОЛОГИЧЕСКИЕ СВОЙСТВА. ЗОКОР ФОРТЕ симвастатин представляет собой гиполипидемический препарат, получаемый синтетическим. Зокор Форте - официальная инструкция по применению,. Simvastatin definition of simvastatin by Medical dictionary. Simvastatin - brand name list from. Beside meaning and definition for word "zocor", on this page you can find other interesting information too, like synonyms or related words.noun an oral lipid-lowering medicine trade name Zocor administered to reduce blood cholesterol levels; recommended after heart attacks. Simvastatin acid C25H40O6 CID 64718 - structure, chemical names. may vary between notifications depending on impurities, additives, and other factors. Zocor. Generic Name simvastatin SIM va sta tin Brand Names Zocor. and other heart complications in people with diabetes, coronary heart disease, or other.