This leaflet answers some common questions about CIALIS. It does not take the place of talking to your doctor or pharmacist. Your doctor has weighed the risks of you taking CIALIS against the benefits they expect it will have for you. Your doctor may have prescribed you CIALIS to treat either, or both of these conditions. If you have any concerns about taking this medicine, talk to your doctor or pharmacist. Ask your doctor if you have any questions about why CIALIS has been prescribed for you. Your doctor may have prescribed it for another reason. CIALIS is available only with a doctor's prescription. CIALIS is not intended for use by women, or by children under the age of 18 years. The active ingredient in CIALIS tablets, tadalafil, belongs to a group of medicines called phosphodiesterase type 5 inhibitors. Do not take CIALIS if you are currently taking any nitrates or amyl nitrite. 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Cialis tablets, in 2.5 mg, 5 mg, 10 mg, and 20 mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40 mg (two 20 mg tablets) once per day (OD). On November 21, 2003 the FDA approved tadalafil (as Cialis) for sale in the United States as the third ED prescription drug pill (after sildenafil citrate (Viagra) and vardenafil (Levitra)). Like sildenafil and vardenafil, tadalafil is recommended as an 'as needed' medication. Tadalafil was approved in May 2009 in the United States for the treatment of pulmonary arterial hypertension and is under regulatory review in other regions for this condition. In late November 2008, Eli Lilly sold the exclusive rights to commercialize tadalafil for pulmonary arterial hypertension in the United States to United Therapeutics for an upfront payment of $150 million. Cialis is available in four different dosages of 2.5mg, 5mg, 10mg and 20mg. 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