A woman's decision whether or not to take tamoxifen to help treat breast cancer (or prevent breast cancer) should be made carefully, weighing the benefits and risks to the medication. While the benefits of tamoxifen outweigh the risks for many breast cancer patients, serious complications have been reported in a small percentage of women on tamoxifen. These complications were noted more frequently, and sometimes exclusively, in women over the age of 50. Complications that may occur from the use of tamoxifen include the following: Endometrial cancer (cancer of the lining of the uterus): Post-menopausal women who take tamoxifen and who have not had a hysterectomy (uterus removal) are at a higher risk of developing endometrial cancer than women who are not on tamoxifen. In the NSABP's Breast Cancer Prevention Trial, endometrial cancer occurred 2.5 times more frequently in women who took tamoxifen compared to women who took a placebo (inactive pill). However, the risk of endometrial cancer is still low among women on tamoxifen: approximately 2 out of 1000 women on tamoxifen will develop endometrial cancer. Research suggests that long-term use of tamoxifen among post-menopausal women increases the chances of endometrial problems. Tamoxifen is a medicine that is used to stop the changes caused by estrogen in the woman’s body. Due to the increased level of estrogen, some types of tumors can develop and with the higher amount of estrogen in the body, tumors and even some cancers can begin to grow. Tamoxifen has the purpose to stop this from happening. It is helpful in the prevention of specific sorts of breast cancer especially in those who were exposed to radiation and who already had similar problems. Tamoxifen should be used according to doctor’s recommendations. You should inform your doctor if you are expecting a baby, because this medicine can have harmful effect on the embryo. 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