Tamoxifen discovery

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  1. Tarzan Moderator

    Tamoxifen discovery


    Tamoxifen is currently a drug used in the treatment of breast cancer, and has been used in patients for many years. Now, latest research has indicated that Tamoxifen may hold the potential in treating another disease-- myotubular myopathy—by slowing its progression. Structure of Tamoxifen A severe genetic disease affecting males-- myotubular myopathy weakens all the skeletal muscles from birth leading to paralysis that results in death before two years of age. “The disease affects the X chromosome in one in 50,000 male infants,” states Professor Leonardo Scapozza at the School of Pharmaceutical Sciences at UNIGE’s Faculty of Science. Due to the severity of the disease, researchers have long been motivated to seek treatments—this is when scientists at the University of Geneva (UNIGE), Switzerland in collaboration with the University of Strasbourg, France identified a molecule that not only decreased disease progression of the disease but lengthened life expectancy in animal models. The molecule is Tamoxifen and because it has long been approved for breast cancer, investigators are hopeful that transition to clinical trials for myotubular myopathy will not take too long. Tamoxifen has long been studied to be an antioxidant, anti-fibrotic and most importantly, protective of the mitochondria. Tamoxifen (Nolvadex) has been used for over 40 years to treat hormone-receptor positive early, locally advanced and metastatic breast cancers. Learn about tamoxifen and other hormone therapies for metastatic breast cancer. Hormone receptor-positive breast cancers need estrogen and/or progesterone (female hormones produced in the body) to grow. Tamoxifen attaches to the hormone receptor in the cancer cell, blocking estrogen from attaching to the receptor. This slows or stops the growth of the tumor by preventing the cancer cells from getting the hormones they need to grow. Tamoxifen is a pill taken every day for 5-10 years. For premenopausal women, tamoxifen may be combined with ovarian suppression. The benefits from tamoxifen last long after you stop taking it.

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    Although tamoxifen was available for the untargeted treatment of breast cancer in postmenopausal women during the mid-1970s, a scientific strategy for the appropriate clinical application of tamoxifen was developed in the laboratory to target the drug to the tumours that would respond. Tamoxifen Nolvadex, a hormone therapy drug, is used to treat breast cancers and to lower risk in women at high risk of breast cancer. Read about Tamoxifen side. Tamoxifen is used for the treatment of invasive breast cancer in men and women, the most common type of breast cancer, following surgery and/or radiation and for preventing invasive breast cancer in women at high risk for developing it.

    Tamoxifen Other known alias: Nolvadex, Istubal, Valodex, ICI 46,474 —————— On June 25, 2013 the Scottish Parliament announced that Tamoxifen will now be available for women at high-risk of developing breast cancer. So what is Tamoxifen and how does it reduce the risk of developing breast cancer? First off, Tamoxifen (or initially called ICI 46,474) is a fairly old drug which has been around since the 1960’s when Dr. Dora Richardson of ICI Pharmaceuticals (now Astra Zeneca) first chemically synthesized it and Dr. Arthur Walpole pushed for its continued development. Being such an old drug has allowed it to develop quite the colourful past and highlights the importance of “looking outside the box” when developing new drug treatments. When it was designed and created, scientists were busy trying to produce an anti-estrogen compound (something that could block the function of estrogen). The genes could lead to new ways of diagnosing and treating hormonal breast cancer, also known as oestrogen receptor positive breast cancer, which is responsible for four out of five cases, or 36,000 a year in Britain. The scientists, from the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research (ICR) in London, said the discovery could in the future help patients whose breast cancers do not respond to drugs like tamoxifen. They located the genes - named C6ORF96, C6ORF97 and C6ORF211 - in a very well studied part of the human genome, next to the oestrogen receptor gene, which is the main driver of hormonal breast cancer. Dr Anita Dunbier, lead author of the study, which is published in the journal PLo S Genetics, said: "This is a surprising discovery. We found these genes in a place we thought we knew a lot about - it is like finding gold in Trafalgar Square. "We now have to look further at how these genes work, but the discovery could lead to possible new therapies that will benefit women with breast cancer in the future." She added: "What we have found helps us understand more about this type of breast cancer and provides some potential avenues of therapy." She explained that most drugs - such as aromatase inhibitors - targeted the oestrogen receptor itself. However, they did not target genes that were associated with the receptor but separate from it - genes which she said could help tumours resist today's drugs.

    Tamoxifen discovery

    Tamoxifen Дисковери - news-, Tamoxifen for Breast Cancer Treatment - Side Effects Susan G.

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  5. Discovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability.

    • Discovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets..
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    Discovery of a Tamoxifen-Related Compound that Suppresses Glial l-Glutamate Transport Activity without Interaction with Estrogen Receptors. Tamoxifen, sold under the brand name Nolvadex among others. Since his discovery, an entirely new field of cancer research has developed. Overall, the impact of tamoxifen on healthcare, drug discovery, and cancer cell biology has proved to be extremely beneficial but the process took more than 40 years.

     
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