Tamoxifen discovery

Discussion in 'Costco Pharmacy Pricing' started by vdv, 12-Dec-2019.

  1. happydead Guest

    Tamoxifen discovery


    Tamoxifen is currently a drug used in the treatment of breast cancer, and has been used in patients for many years. Now, latest research has indicated that Tamoxifen may hold the potential in treating another disease-- myotubular myopathy—by slowing its progression. Structure of Tamoxifen A severe genetic disease affecting males-- myotubular myopathy weakens all the skeletal muscles from birth leading to paralysis that results in death before two years of age. “The disease affects the X chromosome in one in 50,000 male infants,” states Professor Leonardo Scapozza at the School of Pharmaceutical Sciences at UNIGE’s Faculty of Science. Due to the severity of the disease, researchers have long been motivated to seek treatments—this is when scientists at the University of Geneva (UNIGE), Switzerland in collaboration with the University of Strasbourg, France identified a molecule that not only decreased disease progression of the disease but lengthened life expectancy in animal models. The molecule is Tamoxifen and because it has long been approved for breast cancer, investigators are hopeful that transition to clinical trials for myotubular myopathy will not take too long. Tamoxifen has long been studied to be an antioxidant, anti-fibrotic and most importantly, protective of the mitochondria. Tamoxifen (Nolvadex) has been used for over 40 years to treat hormone-receptor positive early, locally advanced and metastatic breast cancers. Learn about tamoxifen and other hormone therapies for metastatic breast cancer. Hormone receptor-positive breast cancers need estrogen and/or progesterone (female hormones produced in the body) to grow. Tamoxifen attaches to the hormone receptor in the cancer cell, blocking estrogen from attaching to the receptor. This slows or stops the growth of the tumor by preventing the cancer cells from getting the hormones they need to grow. Tamoxifen is a pill taken every day for 5-10 years. For premenopausal women, tamoxifen may be combined with ovarian suppression. The benefits from tamoxifen last long after you stop taking it.

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    Tamoxifen a most unlikely pioneering medicine. Tamoxifen a most unlikely pioneering medicine. Nature Reviews Drug Discovery volume 2, pages 205. Tamoxifen is currently a drug used in the treatment of breast cancer, and has been used in patients for many years. Now, latest research has indicated that. Although tamoxifen was available for the untargeted treatment of breast cancer in postmenopausal women during the mid-1970s, a scientific strategy for the appropriate clinical application of tamoxifen was developed in the laboratory to target the drug to the tumours that would respond.

    Tamoxifen Other known alias: Nolvadex, Istubal, Valodex, ICI 46,474 —————— On June 25, 2013 the Scottish Parliament announced that Tamoxifen will now be available for women at high-risk of developing breast cancer. So what is Tamoxifen and how does it reduce the risk of developing breast cancer? First off, Tamoxifen (or initially called ICI 46,474) is a fairly old drug which has been around since the 1960’s when Dr. Dora Richardson of ICI Pharmaceuticals (now Astra Zeneca) first chemically synthesized it and Dr. Arthur Walpole pushed for its continued development. Being such an old drug has allowed it to develop quite the colourful past and highlights the importance of “looking outside the box” when developing new drug treatments. When it was designed and created, scientists were busy trying to produce an anti-estrogen compound (something that could block the function of estrogen). The genes could lead to new ways of diagnosing and treating hormonal breast cancer, also known as oestrogen receptor positive breast cancer, which is responsible for four out of five cases, or 36,000 a year in Britain. The scientists, from the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research (ICR) in London, said the discovery could in the future help patients whose breast cancers do not respond to drugs like tamoxifen. They located the genes - named C6ORF96, C6ORF97 and C6ORF211 - in a very well studied part of the human genome, next to the oestrogen receptor gene, which is the main driver of hormonal breast cancer. Dr Anita Dunbier, lead author of the study, which is published in the journal PLo S Genetics, said: "This is a surprising discovery. We found these genes in a place we thought we knew a lot about - it is like finding gold in Trafalgar Square. "We now have to look further at how these genes work, but the discovery could lead to possible new therapies that will benefit women with breast cancer in the future." She added: "What we have found helps us understand more about this type of breast cancer and provides some potential avenues of therapy." She explained that most drugs - such as aromatase inhibitors - targeted the oestrogen receptor itself. However, they did not target genes that were associated with the receptor but separate from it - genes which she said could help tumours resist today's drugs.

    Tamoxifen discovery

    Breast cancer gene discovery 'like finding gold' - Telegraph, Hope for Severe Muscle Disease from Breast Cancer Drug 'Tamoxifen.

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  3. Tamoxifen, sold under the brand name Nolvadex among others. Since his discovery, an entirely new field of cancer research has developed.

    • Tamoxifen - Wikipedia.
    • Tamoxifen ICI46,474 as a targeted therapy to treat and prevent breast..
    • Tamoxifen Discovery Drugs.

    A new mouse study shows that basal-like breast tumors can be converted into a subtype of breast cancer that is susceptible to estrogen. Discovery of a Tamoxifen-Related Compound that Suppresses Glial l-Glutamate Transport Activity without Interaction with Estrogen Receptors. How did a failed contraceptive become the first targeted therapy for the treatment of breast cancer? The transformation of tamoxifen, from.

     
  4. bron XenForo Moderator

    To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more DOXYCYCLINE (dox i SYE kleen) is a tetracycline antibiotic. It is used to treat many kinds of infections, like dental, skin, respiratory, and urinary tract infections. It also treats acne, Lyme disease, malaria, and certain sexually transmitted infections. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. They need to know if you have any of these conditions: -liver disease -long exposure to sunlight like working outdoors -stomach problems like colitis -an unusual or allergic reaction to doxycycline, tetracycline antibiotics, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding Take this medicine by mouth with a full glass of water. It is best to take this medicine without food, but if it upsets your stomach take it with food. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply. -antacids -barbiturates -birth control pills -bismuth subsalicylate -carbamazepine -methoxyflurane -other antibiotics -phenytoin -vitamins that contain iron -warfarin This list may not describe all possible interactions. Doxycycline Tablets LloydsPharmacy Online Doctor UK Buy Doxycycline Next Day Delivery — Certified Pharmacy Online! Doxycycline monohydrate - Blink Health Rx - Best Prescription Online.
     
  5. malina07 XenForo Moderator

    While clonidine is not as commonly abused as other classes of drugs, there can be a risk of dependence in some individuals. Its use alongside opiates poses a particular risk for abuse and subsequent withdrawal symptoms. Learn more about clonidine, its uses, and the symptoms and risks of withdrawal. While clonidine is not as addictive as other classes of drugs, users may become dependent on it. Some reports suggest that using clonidine may increase the effect and duration of certain drugs, particularly opiates. As such, those using clonidine with alcohol or drugs may experience more significant dependence. Additional symptoms of withdrawal from clonidine may occur if it is being taken in conjunction with prescription medications, alcohol or other narcotics. Clonadine for Opiate Withdrawal - Opium Withdrawal - Clonidine dose in opiate withdrawal - Addiction Substance Abuse. Clonidine narcotic withdrawal - MedHelp
     
  6. Alex GM Guest

    PCOS Insulin and Metformin Center for Young Women's Health Oct 4, 2018. Young women with PCOS often have elevated insulin levels and are more likely to develop diabetes. Metformin is a medication often.

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  7. Katya_V Moderator

    Oral Prednisolone Dosing in Children Hospitalized With Asthma - Full. Systematic reviews of the literature have called for a clinical trial to evaluate the effect of different doses of corticosteroids in treating pediatric asthma patients.

    Oral Prednisolone Dosing in Children Hospitalized With Asthma.