Tamoxifen for ovarian cancer

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  1. krutimvertim Well-Known Member

    Tamoxifen for ovarian cancer


    New research that came out this month: "Tamoxifen may be a reasonable treatment alternative for patients with biochemical-recurrent ovarian cancer," concluded Dr. Hurteau of the North Shore University Health System in Chicago presented the results of GOG Study 198 at the annual meeting of the Society of Gynecologic Oncologists. Jean Hurteau and his coinvestigators from the Gynecologic Oncology Group (GOG). The rationale for the trial was that the comparative effectiveness of tamoxifen (a hormonal therapy) and thalidomide (an antiangiogenesis agent) was not known in recurrent ovarian cancer. But he cautioned that the findings need to be validated in other randomized trials. All participants had biochemical-recurrent ovarian cancer (defined as a rise in CA 125 of at least twice the upper limit of normal with no evidence of disease by RECIST [Response Evaluation Criteria in Solid Tumors] 1.0 criteria). Tamoxifen plays an important role in the treatment of hormone-driven breast cancer, but evidence for its use in recurrent ovarian cancer is lacking, according to a recent Cochrane Review article in which the authors found no randomized trials on which to base recommendations (Cochrane Database Syst. The investigators reported on 68 women who were randomized to receive a minimum of 200 mg oral thalidomide once daily (with a weekly dose escalation of 100 mg to a maximum of 400 mg), and 70 women randomized to receive 20 mg oral tamoxifen twice daily. The study group included women with FIGO stage III or IV confirmed epithelial ovarian, tubal, or primary peritoneal cancer who had completed first-line chemotherapy and whose CA 125 had normalized. The average age of the patients was 64 years, and 67% had grade III tumors, Dr. The women were assessed for toxicity every 4 weeks, and for disease progression every 12 weeks, until either disease progression or death. Women who received thalidomide had a 31% increased risk of disease progression (hazard ratio, 1.31), compared with those who were given tamoxifen. I am taking it right now and have been for two months. It's hard to know because I've had 19 cycles of chemo, over three lines, and I also take Metformin, Iscador and 40 daily supplements. Hello Xanthic, what are the additional 40 supplements you take? It doesn't seem to be working for me as my CA125 is rising. I've been on it for eight months, after my second recurrence, and so far, so good. My mum is taking a supplement called Savestrol but I would be interested to know of others. It is really good to hear so many ladies with positive results. My doctor wants to wait until my next scan which will be in 1 more month, to make a decision about changing me to some other drug. My mum's specialist here in the UK advised that she should be lucky to survive 5 years!! How can he say such a thing when a lot of you on here have been fighting it a lot longer and at higher stages? We keep searching for alternative therapy to 'hit' back at him with x Her'e my list of daily supplements: 1,000 mg flaxseed oil, 8,400 mg turmeric curcumin with black pepper, 1,500 mg liposomal vitamin C, 600 mg Maitaki mushroom, 650 mg mushroom therapy, 200 mg cranberry extract, 1,020 mg IP-6, 200 mg Co Q10, 200 mg quercetin, 150 mg alpha lipoic acid, 2,500 IU vitamin D3, 500 mg agaricus blazai, 50 mg apigenin, 1,000 mg prickly pear extract, 6 cups green tea, 700 mg resveratrol, 1,000 mg cherry extract, 16 mg pine bark extract, 400 mg DIM, 100 mg zymactive proteoltyic enzyme, 1,000 mg AHCC , 500 mg moringa, 375 broccoli extract, 800 mg citrus pectin, 500 mg ginger, 500 mg kale extract, 500 mg lingonberry extract, plus Iscador injections every six days, 500 mg Metformin, 20 mg tamoxafin. Each chemo drug will have a different effect on each of us although, of course, there are standardized protocols. Basically, my thought is one size does NOT fit all of us. So, I'm trying anything and everything that has some science to support it.

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    New research that came out this month "Tamoxifen may be a reasonable treatment alternative for patients with biochemical-recurrent ovarian cancer," concluded Dr. Hi, Yes, i had borderline ovarian cancer for 3 years and my ca125 started going up unexpectedly from 12 to 66, then after starting tamoxifen it more then. Chemotherapy in platinum-resistant ovarian cancer PROC aims for palliation and prolonging of progression-free survival PFS. This study compares Health.

    Dear All, Many of you know my story; I am a 6 and half year survivor (11/15/02) who did get 3 and half years of remission. I have been on Carbo, Taxol, and Gemzar my first 10 treatments, had the second look surgery in Aug. I am still recovering but a study was done on my tumors to find that they were indeed estrogen positive. 2003, more cancer found; so we opted for intraperitoneal chemo of Cisplatinum; they inserted the port; surgeon accidentally poked a hole in my intestine; I nearly died; but the peritonitis kept my cancer at bay for 3 and half years. 2006 - May 2007 I was on Avastin until I got some severe Abdominal Blockages; took about a 15 month break from chemo then had another severe blockage and lost about 20 lbs; started back on Avastin and Etoposide in Aug. Well my oncologist/chemo doctor prescribed Tamoxifen for my current chemo to see if it will work on shrinking some tumors that are on top of my rib cage. Well then an alien looking tumor started to look as if it were going to burst through my tummy; it's trippy in my blog to watch and read this progression, but I had my 5th major abdominal surgery on May 15, 2009. Well I had a severe Adbominal Blockage and we were able to avoid surgery. Has anyone heard of having Tamoxifen to Treat Recurrent Ovarian Cancer? Thanks, Jayne My doctor treats patients with Tamoxifen and it works for some people. Last summer he thought I needed a break from chemo and had me take the Tamoxifen for 4 months. I was diagnosed stage 3c Sept 2005 and had successful surgery followed by 6 x Carbo/Taxol. My CA125 was 212 at diagnosis and after treatment went down to 19. Unfortunately, after 5 months CA125 started to rise until Feb this year when it rose to 100. I had CT scan which showed lymph nodes nad increased to over 3cm. I started on Caelyx in April 07 and had 6 treatments Half way through treatments the lymph nodes had reduced to just over 1cm. I finished treatments in Sept and CA125 was 122 (this was after 5 treatments as CA125 sample is taken before each treatment starts). I had further scan and it showed lymph nodes were over 2cm.

    Tamoxifen for ovarian cancer

    Femara for ovarian cancer - MedHelp, Tamoxifen and ovarian cancer - Ovarian Cancer - MedHelp

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  7. BRCA1 mutation carriers have a high rate of both breast and ovarian cancer. Tamoxifen is a selective estrogen receptor modulator SERM, which is used for.

    • Tamoxifen and the Risk of Ovarian Cancer in. - PubMed Central..
    • Chemotherapy vs tamoxifen in platinum-resistant ovarian cancer a..
    • Ovarian Cancer Symptoms & Treatment Cleveland Clinic.

    Tamoxifen is an important drug for treating breast cancer. Ovarian cancer cells are known to possess receptors for hormones and may thus also respond to. For women at higher risk of breast cancer, drugs such as tamoxifen and raloxifene have been shown to help reduce the risk. I am wondering if anyone has been on or knows anything aboutTamoxifen for Ovarian Cancer. If so, what are your outcome or thoughts on it. It has a lot of side effects.

     
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