To test the effectiveness and acceptability of an outpatient medical abortion protocol with 200 mg mifepristone and 400 mcg sublingual misoprostol at 64–70 days' last menstrual period (LMP) and compare it to the already known efficacy of the 57–63 days' LMP gestational age range. We conducted a prospective, comparative open-label trial in six hospitals and clinics in Ukraine, Georgia, India and Tunisia. We enrolled 714 reproductive age women with pregnancies 57 to 70 days who presented requesting abortion. Medical abortions were managed with the current service delivery protocol (200 mg oral mifepristone followed in 24–48 h by 400 mcg sublingual misoprostol). Data on safety, efficacy and acceptability were collected. The main outcome measure was complete abortion without surgical intervention at any point. Success rates did not differ significantly in the two groups [57–63-day group: 94·8%; 64–70-day group: 91.9%; Relative Risk (RR): 0.79 (0.61–1.04)]. Ongoing pregnancy rates also did not differ significantly (57–63 days: 1.8%; 64–70 days: 2.2%; RR: 1.10 (0.65–1.87)]. Remember this information is useful for abortion with pills in pregnancies that are 10 weeks or less counted from the first day of your menstrual period. If you are more then 10 weeks pregnant we are not trained to support you but we will do our best to refer you to an organization that is. Using only Misoprostol is very effective (85%) To confirm if abortion pills are safe for you we recommend you to read this information, click here. If the pills you are getting have a different dosage of mcg, you will need to recalculate so you can get and use the correct amount of medication. If you are not sure if this procedure is a good option for you, contact us. If you have any questions or something is not clear to you, please do not hesitate to contact us. We are here to support you throughout your abortion process. This step is not required, but we highly recommend it. Ibuprofen will reduce the intensity of the cramps and help you manage the possible side effects of Misoprostol such as headache, fever and/or chills. Where can i get cialis cheap Xanax 20 mg Amoxicillin ear ache Should cipro be taken with food Cytotec oral tablets contain either 100 mcg or 200 mcg of misoprostol. after single doses show a linear relationship with dose over the range of 200-400 mcg. Aug 4, 2016. Pongsatha et al compared a vaginal misoprostol loading dose regimen 600 mcg, then 400 mcg every 6 h with a non-loading dose regimen. CYTOTEC 200 microgram q.i.d. coadministered with NSAIDs is superior to placebo. show a linear relationship vs. dose over the dose range of 200 to 400 mcg. A 2011 Cochrane review to compare different methods of second trimester medical termination of pregnancy for their efficacy and side-effects (Wildschut) found: "A range of doses of vaginally administered misoprostol has been used. No randomised trials comparing doses of misoprostol were identified; however low doses of misoprostol appear to be associated with fewer side-effects while moderate doses appear to be more efficient in completing abortion. MINNEAPOLIS — Sublingually administered misoprostol was significantly more effective than the drug given orally after mifepristone for medical abortion in a prospective randomized trial, Sheila Raghavan said at the annual meeting of the Association of Reproductive Health Professionals.“Medical abortion is becoming more popular and is preferred by women because of the ease of administration and convenience,” Ms. Misoprostol typically has been administered orally or vaginally for abortion, although this use is off-label and, in fact, the labeling for misoprostol carries a boxed warning stating that its use by pregnant women can not only cause abortion but also birth defects and uterine rupture. Pharmacokinetic studies have shown higher bioavailability and more rapid absorption when given sublingually. Initial investigations into this route of administration used high doses of sublingual misoprostol and found a high—98%—efficacy rate, but also showed a high rate of side effects. For investigation of whether a lower dose (400 mcg) of misoprostol given sublingually after 200 mg oral mifepristone would be effective, tolerable, and acceptable to women, 480 women who ranged in age from 18 to 46 years who were presenting for termination of intrauterine pregnancy were enrolled in the study. Approximately 55% of the women had had previous abortions. Raghavan, who is program research coordinator at Gynuity Health Projects, a reproductive health research and technical assistance organization in New York City. For example, in one study comparing sublingual and vaginal misoprostol given in a dose of 800 mcg, 54% of women receiving the sublingual drug experienced nausea, compared with 32% of those receiving the drug vaginally (Hum. A total of 240 women were randomized to receive the oral drug, and 240 to receive the sublingual drug, at home 24 hours after receiving 200 mg oral mifepristone in the clinic. Two weeks later they were seen for follow-up assessment, at which time success rates of 98.7% and 94% were seen in the sublingual and oral groups respectively, a difference that statistically favored the sublingual route, Ms. Four cases, all in the oral group, required surgical intervention. Fever and chills occurred more frequently in the sublingual group, with 28% of patients reporting these side effects, compared with 18% in the oral group. The nausea lasted significantly longer in the oral group, however, and more than 80% of women in both groups reported that the side effects were acceptable or very acceptable. Cytotec 400 mcg Misoprostol Dosage Guide with Precautions -, Misoprostol for second trimester abortion query bank - RCOG Clomid metformin Of misoprostol for second trimester induction at. 14–30 weeks showed that 400 mcg of vaginal misoprostol. 6 hourly provided the optimal regimen, with a shorter. Misoprostol - Obstetrics and Gynecology. Cytotec - Medsafe. Misoprostol Oral Uses, Side Effects, Interactions, Pictures, Warnings.. Medscape - Indication-specific dosing for Cytotec misoprostol. 25 mcg 1/4 of 100-mcg oral tablet intravaginally initially, then repeat at intervals not to. You will need 12 misoprostol pill. Each pill should be 200 mcg. If the pills you are getting have a different dosage of mcg, you will need to recalculate so you can. To test the effectiveness and acceptability of an outpatient medical abortion protocol with 200 mg mifepristone and 400 mcg sublingual misoprostol at 64–70.