This medication is a retinoid, prescribed for acne vulgaris and acute promyelocytic leukemia. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you. Wearing layers of clothes or summer clothes and staying in cool places may help. It slows or stops the growth of cancer cells in the body. Tretinoin causes certain cancer cells to mature into normal cells. Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Stay away from people with infections, colds, or flu. Talk with your doctor about a stool softener or laxative. Drinking more liquids, working out, or adding fiber to your diet may help. 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