Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo. The antidepressants available in the United States are classified by either their chemical structure (e.g., the tricyclics, TCAs) or their actions on neurotransmitters (e.g., SSRIs and MAOIs) or simply as “other” (e.g., Wellbutrin). In the future, the classification of the antidepressants may become more confusing as new drugs are developed that are neither TCAs, SSRIs, or MAOIs. A variety of substances (and more are being found each day) with differing chemical structures have antidepressant abilities. However, no group is known to be more effective than the others. The tricyclic antidepressants have a three-ring nucleus and are norepinephrine and serotonin reuptake inhibitors. Trade names included in this group of drugs as of 2002 are: Etrafon, Limbitrol, Norpramin, Sinequan, Surmontil, and Vivactil. The heterocyclic antidepressants were introduced between 19. They consist of an intertwined circular structure called benzene rings. Where to buy ventolin in hong kong Nolvadex gynecomastia Sertraline = Zoloft; Lustral. PubChem 68617. Molecular formula C17H17Cl2N. Molecular weight 306.23 g/mol. IUPAC 1S,4S-4-3. ZOLOFT is contraindicated in patients with a hypersensitivity to sertraline or any of the inactive ingredients in ZOLOFT. Oral Concentrate ZOLOFT oral concentrate is contraindicated with ANTABUSE disulfiram due to the alcohol content of the concentrate. Properties. State Solid; Experimental Properties. using admetSAR, a free tool for evaluating chemical ADMET properties. Efficacy has been demonstrated in depression, dysthymia, OCD, social anxiety, panic disorder, PTSD, premature ejaculation, and premenstrual dysphoric disorder. It's also sometimes used for eating disorders. The core effect of the substance is that it alters mood. This could mean less anxiety, less depression, a more positive outlook, improved cooperation with others, and greater assertiveness. SSRIs may initially worsen symptoms like depression and anxiety in some people. This changes over a period of weeks, with the efficacy building over time. Some benefits in depression may be noticed in the first 1-2 weeks, but the greatest clinical efficacy arrives in the first couple months. Sertraline is the hydrochloride form of sertraliine. Sertraline belongs to the selective serotonin reuptake inhibitor (SSRI) class antidepressant drug. Sertraline is indicated for the treatment of major depressive disorder in adults as well as obsessive-compulsive disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder and social anxiety disorder occurring in both adults and children. Its exact mechanism of action is still not fully understand. But it is indicated that this drug can selectively inhibit the reuptake of serotonin at the presynaptic membrane, increasing serotonin levels in the synapses and enhancing serotonergic neurotransmission. This effect seems to be related to the antidepressant effect of sertraliine. https://en.wikipedia.org/wiki/Sertraline https:// White or almost white, crystalline powder. Used as an antidepressant antibacterial A selective ST inhibitor Ch EBI: A hydrochloride resulting from the reaction of equimolar amounts of sertraline and hydrogen chloride. Zoloft chemical structure What brain chemical does Zoloft work on, Zoloft tablet Generic, Side effects, Interchangeable drugs. Cialis yahoo answersXanax structureBest way to buy generic viagraBuy viagra scotland Structure, properties, spectra, suppliers and links for Sertraline hydrochloride, 79559-97-0. Sertraline hydrochloride C17H18Cl3N ChemSpider. Sertraline DB01104 - Sertraline - DrugBank. Zoloft Sertraline HCl Tablets/Oral Concentrate - FDA. The antidepressants available in the United States are classified by either their chemical structure e.g. the tricyclics, TCAs or their actions on neurotransmitters e.g. SSRIs and MAOIs or simply as “other” e.g. Wellbutrin. Visit ChemicalBook To find more Sertraline hydrochloride79559-97-0 information like chemical properties,Structure,melting point,boiling point,density. Zoloft Sertraline and Prozac Fluoxetine both belong to the SSRI Selective Serotonin Reuptake Inhibitors group of effect and working of most SSRI is fairly similar, but individual chemical composition of each drug determines which works best for a specific individual on specific symptoms.