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Discussion in 'Canadian Meds' started by Royalist, 01-Sep-2019.

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    The major aims were to 1) assess the reliability of pediatrician-diagnosed allergic reactions to commonly used β-lactam antibiotics based on the examination at the time of reaction followed by elective skin testing and oral challenge, and 2) monitor prospectively the predictive value of negative skin testing for subsequent reactions to antibiotics administered. Skin testing with penicillin G, commercial benzylpenicilloyl phosphate (Pre-pen), penicillin minor determinant mixture (MDM), ampicillin, cefazolin, cefuroxime, and/or ceftriaxone was performed according to the suspected cause of the reaction. This was followed by an oral challenge, repeat testing, and prospective follow-up if no reactions were observed. Overall, 84 (34%) of 247 patients had an immunoglobulin E (Ig E)-type reaction on skin testing or oral challenge. Twenty-seven (32%) of 85 suspected penicillin reactions, 53 (34%) of 156 suspected amoxicillin reactions, and 13 (50%) of 26 suspected cephalosporin reactions were felt to be Ig E-mediated. Positive skin tests were observed in 20 patients with non-Ig E-type adverse reactions, including 15 patients with only a pruritic polymorphous rash. No reactions to oral challenge were severe after negative skin testing. What is the risk of a repeat reaction to amoxicillin or a cephalosporin in. The new cross reactivity study - Lexicomp Newsletter Interactions between Amoxicillin Oral and selected-cephalosporins.
     
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