Tamoxifen to treat gynecomastia

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  1. Ru5i4 New Member

    Tamoxifen to treat gynecomastia


    Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Use a barrier form of birth control (such as a condom or diaphragm with spermicide) while you are using this medication and for at least 2 months after your treatment ends. Tamoxifen may also be used for purposes not listed in this medication guide. You should not use tamoxifen if you are allergic to it, or if you have a history of blood clots in your veins or your lungs, or if you are also taking a blood thinner such as warfarin (Coumadin). Before using this medicine, tell your doctor if you have liver disease, high triglycerides (a type of fat in the blood), a history of cataract, or a history of stroke or blood clot. Also tell your doctor if you if you are receiving chemotherapy or radiation treatment. New research reassessing clinical data from trials, which investigate ways of treating side effects of therapy for prostate cancer, finds that tamoxifen, an anti-estrogen used to treat breast cancer, is also able to suppress gynecomastia and breast pain in men. Prostate cancer is one of the most common cancers in men and early treatment is usually very successful. reassessing clinical data from trials, which investigate ways of treating side effects of therapy for prostate cancer, finds that tamoxifen, an anti-estrogen used to treat breast cancer, is also able to suppress gynecomastia and breast pain in men. Prostate cancer is one of the most common cancers in men and early treatment is usually very successful. Androgen-suppression therapy is often used to slow down progression of advanced disease. However, unwanted side effects of anti-androgen treatment, such as breast enlargement, can stop men from seeking treatment for their cancer. Testosterone can drive the growth of prostate cancer and anti-androgens are used to inhibit prostate cancer growth by preventing testosterone from binding to androgen receptors.

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    Gynecomastia is condition in which the gland tissue enlarges the the male breasts. It's is the result of an imbalance of hormones caused by puberty. Epithelial hyperplasia and stromal edema or fibrous tissue with atrophic glands, depending on the type of gynecomastia Evaluation of tamoxifen and anastrozole in the prevention of gynecomastia and breast pain induced by bicalutamide monotherapy of prostate cancer. J. Clin. Oncol.23,808–815 2005. • Describes the prevention of anti-androgen-induced gynecomastia by tamoxifen and shows its superiority to the aromatase inhibitor, anastrozole.

    Low testosterone levels in men can sometimes lead to a condition called gynecomastia, or the development of larger breasts. It’s responsible for male physical features and also affects a man’s sex drive and mood. When there’s an imbalance of the body’s hormones in men, including testosterone, gynecomastia can develop. Both low testosterone and gynecomastia are often treatable. It’s important to first understand the underlying causes for each condition. This is called hypogonadism, or “low T.” According to the Urology Care Foundation, 1 in 4 men over the age of 45 have low T. Having low testosterone levels can lead to several complications: The male body produces both testosterone and estrogen, although estrogen is usually found at low levels. If a man’s testosterone levels are especially low in comparison to estrogen, or if there is an excess of estrogen activity relative to testosterone, larger breasts may develop. When boys hit puberty and there’s a noticeable change in hormonal activity in the body, gynecomastia may appear. Tamoxifen has emerged as a potential management option for gynecomastia and breast pain due to non-steroidal antiandrogens, and it is considered an alternative to surgery or radiotherapy. The objective of this systematic review was to assess the benefits and harms of tamoxifen, in comparison to other treatment options, for either the prophylaxis or treatment of breast events induced by non-steroidal antiandrogens in prostate cancer patients. We searched CENTRAL, MEDLINE, EMBASE, reference lists, the abstracts of three major conferences and three trial registers to identify ongoing randomized controlled trials (RCTs). Two authors independently screened the articles identified, assessed the trial quality and extracted data. The protocol was prospectively registered (CRD42011001320; Four studies were identified. Tamoxifen significantly reduced the risk of suffering from gynecomastia (risk ratio 9RR0 0.10, 95% CI 0.05 to 0.22) or breast pain (RR 0.06, 95% CI 0.02 to 0.17) at six months compared to untreated controls. Tamoxifen also showed a significant benefit for the prevention of gynecomastia (RR 0.22, 95% CI 0.08 to 0.58) and breast pain (RR 0.25, 95% CI 0.10 to 0.64) when compared to anastrozole after a median of 12 months.

    Tamoxifen to treat gynecomastia

    Enlarged breasts in men gynecomastia - Diagnosis and treatment., Pathology Outlines - Gynecomastia

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  7. Letrozole is approved by the United States Food and Drug Administration FDA for the treatment of local or metastatic breast cancer that is hormone receptor positive.

    • Letrozole - Wikipedia.
    • Gynecomastia Incidence, Causes, and Treatment.
    • Tamoxifen Uses, Dosage, Side Effects -.

    A randomized trial comparing tamoxifen therapy vs. tamoxifen prophylaxis in bicalutamide-induced gynecomastia. Clin Genitourin Cancer 2012; 4. Tyrrell CJ, Payne H, Tammela TL, et al. Prophylactic breast irradiation with a single dose of electron beam radiotherapy 10 Gy significantly reduces the incidence of bicalutamide-induced gynecomastia. Tamoxifen also showed a significant benefit for the prevention of gynecomastia RR 0.22, 95% CI 0.08 to 0.58 and breast pain RR 0.25, 95% CI 0.10 to 0.64 when compared to anastrozole after a median of 12 months. Medications used to treat breast cancer and other conditions, such as tamoxifen Soltamox, raloxifene Evista and aromatase inhibitors Arimidex, may be helpful for some men with gynecomastia. Although these medications are approved by the Food and Drug Administration, they have not been approved specifically for this use.

     
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