A team from the University of Rochester Medical Center has shown scientifically what many women report anecdotally: that the breast cancer drug tamoxifen is toxic to cells of the brain and central nervous system, producing mental fogginess similar to "chemo brain." A team from the University of Rochester Medical Center has shown scientifically what many women report anecdotally: that the breast cancer drug tamoxifen is toxic to cells of the brain and central nervous system, producing mental fogginess similar to "chemo brain." , researchers also report they've discovered an existing drug compound that appears to counteract or rescue brain cells from the adverse effects of the breast cancer drug. D., professor of Biomedical Genetics and director of the UR Stem Cell and Regenerative Medicine Institute, said it's exciting to potentially be able to prevent a toxic reaction to one of the oldest and most widely used breast cancer medications on the market. Although tamoxifen is relatively benign compared to most cancer treatments, it nonetheless produces troubling side effects in a subset of the large number of people who take it. By studying tamoxifen's impact on central nervous system cell populations and then screening a library of 1,040 compounds already in clinical use or clinical trials, his team identified a substance known as AZD6244, and showed that it essentially eliminated tamoxifen-induced killing of brain cells in mice. "As far as I know, no one else has discovered an agent that singles out and protects brain and central nervous system cells while also not protecting cancer cells," Noble said. "This creates a whole new paradigm; it's where we need to go." The research is the result of two separate but related projects from Noble's lab. One investigates the science underlying a condition known as "chemo brain," and another is looking at how to exploit tamoxifen's attributes for use in other types of cancer besides early-stage, less-aggressive breast cancer. (The drug is a type of hormonal therapy, which works by stopping the growth of estrogen-sensitive tumors.) In the paper, Noble's team first identified central nervous system (CNS) cells that are most vulnerable to tamoxifen toxicity. Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Use a barrier form of birth control (such as a condom or diaphragm with spermicide) while you are using this medication and for at least 2 months after your treatment ends. Tamoxifen may also be used for purposes not listed in this medication guide. You should not use tamoxifen if you are allergic to it, or if you have a history of blood clots in your veins or your lungs, or if you are also taking a blood thinner such as warfarin (Coumadin). Before using this medicine, tell your doctor if you have liver disease, high triglycerides (a type of fat in the blood), a history of cataract, or a history of stroke or blood clot. Also tell your doctor if you if you are receiving chemotherapy or radiation treatment. Zoloft lowest dosage Valtrex treats Can you buy viagra with paypal Memory changes with Tamoxifen? I have been taking Tamoxifen since February of this year. My memory and concentration have gotten so bad that I quit my job after. Tamoxifen; ovarian shutdown or removal;. If your memory loss is a side effect of breast cancer treatment, try the following tips to help stimulate your memory Hormonal therapies, such as tamoxifen and aromatase inhibitors anastrozole, letrozole and exemestane, may also affect your memory and concentration. Feeling extremely tired fatigue is a common side effect of cancer treatment. It can cause problems with concentration and memory. Reducing fatigue may help improve these problems. Memory is your mind's ability to keep and remember information. You go to another room to get something, only you forget what you needed when you get there. Maybe you can't find your car keys one day and your glasses the next. These occasional memory lapses are normal signs that your brain is a little overworked. But memory loss also can be part of a bigger problem that's more serious than just misplaced car keys. If you answer “yes” to them, ask your doctor to evaluate your memory loss. There are other treatment side effects that can affect your memory, including trouble sleeping and fatigue. Memory loss also can be a side effect of other medicines, such as steroids, anti-depressants, sleeping pills, and pain medications. Talk to your doctor if you think a medication may be contributing to your memory loss. Your head feels foggy — you just called a child or friend by the dog’s name and the dog is wondering why it hasn’t been fed. As a woman with breast cancer, chances are you’ve heard of chemo brain but you’re not going through chemotherapy. Instead, your doctor has you on anti-estrogen medication. However, you have experienced tamoxifen side effects and have noticed a difference in your ability to focus, remember information, or keep track of everyday tasks. For women taking anti-estrogen drugs such as tamoxifen, these changes in cognitive function have been described as brain fog, a term used to describe mental confusion, forgetfulness or lack of mental clarity. For women on tamoxifen who experience these symptoms, it may be due to low estrogen levels, which can tamper with specific cells in your brain. The root of your problems may be due to your anti-estrogen therapy. Tamoxifen memory Mental fog with tamoxifen is real; possible antidote., Memory Loss A Side Effect of Treatment - Que es viagraBuy cialis cheap onlineSertraline hcl 100mg Patients and Methods. The National Surgical Adjuvant Breast and Bowel Project's Study of Tamoxifen and Raloxifene STAR study was a randomized clinical trial of tamoxifen 20 mg/d or raloxifene 60 mg/d in healthy postmenopausal women at increased risk of breast cancer. Effects of Tamoxifen and Raloxifene on Memory and Other.. Concentration and memory problems - Information and support.. Tips on Tamoxifen Side Effects -. 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