Metformin in diabetes

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  1. Allar Moderator

    Metformin in diabetes

    In Medieval Europe, the Gallega officinalis plant was used as a folk medicine to treat diabetes. In the late 1800s, the plant was found to be rich in guanidine, and a subsequent animal study in 1918 showed that guanidine had a blood glucose-lowering effect. However, guanidine proved to be too toxic for clinical use. In 1929, dimethylbiguanide, which included phenformin and metformin, was synthesized. These compounds preserved the glucose-lowering effect of their parent compounds but with reduced toxicity. Phenformin is more potent than metformin in improving hyperglycaemia, but the high occurrence of lactic acidosis led to the withdrawal of phenformin from the market in the 1970s. This adverse event is extremely rare with metformin, allowing its use in an increasingly comprehensive way for the treatment of hyperglycaemia in patients with type 2 diabetes (T2D). Gestational diabetes (GDM) is a condition that manifests as high blood sugar levels (hyperglycemia) during pregnancy in previously healthy women. It develops as a result of increased maternal body's resistance to insulin - a major hormone that allows for utilisation of glucose (sugar taken in with food) within cells. It was found out that GDM occurs more frequently in overweight women but also in women with a history of certain conditions such as polycystic ovary syndrome (PCOS). Usually, GDM disappears after pregnancy is completed but it is associated with some serious hazards for women and her unborn child, if untreated properly. Diet is a first-choice treatment but sometimes insulin therapy must be initiated if keeping a diet alone is not enough to maintain blood sugar within recommended values. Insulin therapy is effective but it requires several injections during each day and insulin is a strong acting hypoglycemic agent that may induce rapid falls in blood sugar, also dangerous for mother and unborn child. In the investigators study, the investigators would like to investigate if metformin that is a commonly used hypoglycemic drug can be effectively used for GDM treatment.

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    Metformin tablets effectively treat Type 2 diabetes and control blood sugar levels. Metformin is the most effective and commonly prescribed medication for treating type 2 diabetes. Jan 2, 2018. Researchers say metformin has the lowest adherence rate of any major diabetes drug. However, patients say there are ways to improve that. Metformin became the first-line choice for treatment of type 2 diabetes T2D in the course of the UKEffects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.

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    Metformin in diabetes

    Effects of metformin - Diabetes in Control -, Diabetes Medication Metformin Why Patients Stop Taking It - Healthline

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  6. Metformin in Type 1 Diabetes. Is this a good or bad idea? J. David Faichney, MD, FACP and. Therefore, when is it reasonable and defensible to prescribe metformin in type 1 diabetes?

    • Metformin in Type 1 Diabetes Diabetes Care.
    • Metformin Effect on Nontargeted Metabolite Profiles in..
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    I have been taking 500 mg of metformin on an empty stomach since being diagnosed with type 2 diabetes in 2000. A nurse recently told me that metformin. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin. Diabetes and Metformin. Metformin is an oral antidiabetic drug, first approved for use in the USA in 1994. It helps control blood sugar in several ways, including decreasing hepatic glucose production.

  7. Polaris Moderator

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