How was viagra discovered

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  1. xronikus Guest

    How was viagra discovered


    The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Ten years ago this month, the Food and Drug Administration's approval of a little blue pill changed the sex lives of millions of men and women. Viagra, the first oral treatment for erectile dysfunction was developed accidentally by scientists at Pfizer Laboratories and was greenlighted for use by the FDA on March 27, 1998."Originally, we were testing sildenafil, the active drug in Viagra, as a cardiovascular drug and for its ability to lower blood pressure,'' Dr. Brian Klee, senior medical director at Pfizer, told French news agency, AFP. "But one thing that was found during those trials is that people didn't want to give the medication back because of the side effect of having erections that were harder, firmer and lasted longer.'' Since its approval, Viagra has been used by 35 million men around the world. It took the taboo out of impotence — former presidential candidate Bob Dole who suffered from erectile dysfunction after surgery for prostate cancer once appeared in a commercial for the drug — and made it easier to treat.

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    Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile. Pfizer originally discovered the medication in 1989 while looking for a treatment for heart related chest pain. It was approved for medical use in the. During the heart clinical trials, researchers discovered that the drug was more effective at inducing erections than treating angina. Pfizer realized ED was an unmet medical need and a major opportunity for financial gain. In 1998, the FDA approved Viagra, the first oral treatment for erectile dysfunction, under a priority review. Feb 16, 2019. The discovery that sildenafil could lead to an erection was an unplanned event. The sildenafil compound was originally developed by Pfizer for.

    In the late 1980s and 90s, they were looking for a potential treatment for hypertension. Early test results were unremarkable—except for one unusual behavior from the male participants. Michael Reitano, explains, “When the study was over, the patients didn’t want to give back the unused medication.” In another study, Reitano notes the discovery of a curious “side effect” of sildenafil. “One nurse noticed something strange when she went around to check the patients’ blood pressure. That’s when she discovered a prominent side effect of the blood pressure medication—erections. To hide the unexpected erections, the men had turned over.” Before Pfizer shelved as a failed high blood pressure medication, this unexpected side effect quickly became the main feature. Further testing (of a more sexual nature) soon followed. On March 27, 1998, Pfizer received FDA approval to sell the new drug as Viagra, the first oral treatment for erectile dysfunction. And the way we talk about and treat erectile dysfunction—and sexual health—has never been the same. Viagra (sildenafil) is one of the most widely-known prescription drug names on the U. ED is a common sexual problem for men and its frequency increases with age. Pfizer realized ED was an unmet medical need and a major opportunity for financial gain. Often dubbed "the little blue pill", Viagra (sildenafil) was the first phosphodiesterase 5 (PDE5) inhibitor approved to treat erectile dysfunction (ED). During the heart clinical trials, researchers discovered that the drug was more effective at inducing erections than treating angina. The sildenafil compound was originally developed by Pfizer for the treatment of hypertension (high blood pressure) and angina pectoris (chest pain due to heart disease). The discovery that sildenafil could lead to an erection was an unplanned event. survey determined about 50 percent of men 40 to 70 years of age experience some degree of ED. In 1998, the FDA approved Viagra, the first oral treatment for erectile dysfunction, under a priority review. At the time of its approval, Viagra had the fastest initial sales growth following its launch of any prescription product, reaching 2008 sales of close to $2 billion.

    How was viagra discovered

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  4. Viagra and many other drugs were discovered by chance. Now science is hoping to change that. Viagra, initially intended as a treatment for a.

    • Viagra and many other drugs were discovered by chance. Now..
    • Viagra How a Little Blue Pill Changed the World -.
    • When and how was Viagra Sildenafil discovered? Dr Seb.

    Dec 11, 2017. Approved 19 years ago, Pfizer Inc.'s Viagra ushered in a. So, if you incidentally discovered prostate cancer or bladder cancer, or something. Mar 24, 2008. Viagra, the first oral treatment for erectile dysfunction was developed accidentally by scientists at Pfizer Laboratories and was greenlighted for. Mar 27, 2013. Wednesday marks the 15th anniversary of Viagra's FDA approval in the United States. Viagra currently holds 45% of the sexual dysfunction.

     
  5. sasha-d-d Moderator

    He has done nothing to injure himself as far as heavy lifting or falling or anything.is 74, weighs 170, 5'10" tall, eats no processed foods, not afraid of good fats but active, bowls, golfs and takes lots of vitamin supplements. He had an MRI last week and they decided he has still has the tendonitis and though the right hurts way more then the left, they say now the left also has a medium size tare in the rotator cuff. for a recurring prostate infection in which he was urinating blood and clots. then the pain came back big time especially in the right shoulder, and less in the left. Several months ago he started having a lot of pain in both shoulders and they decided to x-ray him and found that he had tendonitis in both shoulders, so he was given a cortisone shot in each shoulder and he felt like a young man.he got another prostate infection again back in March and was put on his 4th month of taking Cipro.. We actually have been eating the Atkins way for about 6 years, Meat, cream, cheese, eggs, butter, nuts, fruit, vegetables and low carb bread etc. Anyway, our question to you is "why do you only mention the Achilles tendon? " Aren't any other tendons just as subject to damage from Quinalones? I am confused, because you don't mention anything about shoulder tendons and Josh doesn't either, in fact, he only shows massage on the leg area... Cipro Tendonitis, Tendonitis From Taking Cipro Antibiotics About Cipro cause tendonitis Cipro Tendon Rupture - Bacteria Home Page
     
  6. Joka Moderator

    Clomid - Everything you need to know and make it work - babyMed Jan 18, 2019. The most important thing to know is that Clomid is a medication to. equipment and blood work to tell you the best time to try to conceive.

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