Tamoxifen to prevent breast cancer

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  1. rotveller Guest

    Tamoxifen to prevent breast cancer


    Based on data from the phase III TAM-01 trial presented at the 41st Annual San Antonio Breast Cancer Symposium (SABCS), investigators concluded that giving women diagnosed with breast intraepithelial neoplasia (IEN) a lower dose of tamoxifen following surgery could be as effective and less toxic than the current standard dose. “We know tamoxifen is effective in prevention, but its toxicity…represents an important barrier for its use in a population at increased risk for breast cancer.” said Andrea De Censi, MD, director of the medical oncology unit at the National Hospital E. Ospedali Galliera–SC Oncologia Medica in Genoa, Italy, who presented the findings at the meeting. The current standard for tamoxifen therapy following surgical removal for this patient population is 20 mg daily for 5 years. However, patient compliance is often an issue due to its toxicity profile. “It is not clear what is the minimal active dose to illicit its biological and clinical effect,” De Censi said. Study investigators hypothesized that a lower dose of tamoxifen over a shorter duration could be equally as effective yet less toxic than the current stand dose. The annual risk of events was calculated to be 11.6 versus 23. patients, representing a 52% reduction in the cumulative risk of disease. The risk of contralateral breast cancer with low-dose tamoxifen was reduced by 75% when compared with placebo (HR 0.24; 95% CI, 0.07-0.87; = .018), suggesting a strong preventative potential. Giving the drug Tamoxifen to women who are at risk for breast cancer can reduce cancer deaths and save money, according to a new study. The results, based on a mathematical model, show Tamoxifen can prevent 29 breast cancer cases and nine breast cancer deaths for every 1,000 women treated. About 34 to 35 women would need to be treated with Tamoxifen to prevent one case of breast cancer, and 102 women would need to be treated to prevent one death, the researchers say. Unlike many treatments, which benefit patients but come with a high price tag, using this drug would save money. For every 1,000 women treated, Tamoxifen would save $47,580, the researchers say. The cost savings arise because the drug prevents breast cancer cases from occurring in the first place. The problem with Tamoxifen is that it comes with some serious side effects.

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    If you don't prevent people from dying, then how valuable is that?" Professor Mike Dixon questioning the benefit of chemoprevention. We searched PubMed without language restrictions up to Aug 30, 2017, using the search terms “early breast cancer”, “adjuvant treatment”, and “anastrozole or exemestane or letrozole” to identify meta-analyses and prospective trials of adjuvant endocrine treatment of postmenopausal women with breast cancer. There’s no magic pill to prevent breast cancer. But there is a medicine that can help lower your risk of getting the disease or of a recurrence.

    If you are on a personal connection, like at home, you can run an anti-virus scan on your device to make sure it is not infected with malware. If you are at an office or shared network, you can ask the network administrator to run a scan across the network looking for misconfigured or infected devices. Another way to prevent getting this page in the future is to use Privacy Pass. Check out the browser extension in the Chrome Store. Early Breast Cancer Trialists’ Collaborative Group. Fisher and coworkers reported that women given tamoxifen for only 5 years for ER-positive breast cancer with negative nodes had improved disease-free survival compared with women randomized to continue tamoxifen more than 5 years (92% vs 86% respectively, P=.003). The optimal duration of treatment for primary prevention has not been determined. Breast cancers in women with the Breast Cancer 1 gene (BRCA1) are more likely to be ER negative. Authors estimated that 36% of participants and 60% of women who developed breast cancer had a greater than 80% chance of having a breast cancer predisposition gene. HRT was allowed, and the study had 90% power to detect a reduction of 50% in breast cancer incidence. Powles and colleagues reported no benefit from tamoxifen in young women with at least one first-degree relative with breast cancer. reported no overall benefit from treatment with tamoxifen in low-risk hysterectomized women, but the trial was underpowered, had a high dropout rate in the first year, and allowed hormone replacement therapy (HRT).

    Tamoxifen to prevent breast cancer

    Tamoxifen Found to Prevent Breast Cancer Deaths in At-Risk Women, Adjuvant anastrozole versus exemestane versus letrozole.

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  5. EVIDENCE-BASED ANSWER. Tamoxifen prevents breast cancer in women older than 60 years and in younger women with equally high risk because of breast disease.

    • Does tamoxifen prevent breast cancer? MDedge Family Medicine.
    • Tamoxifen to Reduce Breast Cancer Risk – Rocky Mountain Cancer..
    • Tamoxifen MedlinePlus Drug Information.

    Metastatic breast cancer, also referred to as metastases, advanced breast cancer, secondary tumours, secondaries or stage 4 breast cancer, is a stage of breast cancer where the disease has spread to distant sites beyond the axillary lymph nodes. For the Patient Tamoxifen Other names APO-TAMOX®, GEN-TAMOXIFEN®, NOLVADEX-D®, NOVO-TAMOXIFEN®, TAMOFEN® • Tamoxifen ta-MOX-i-fen April 20, 2010 Washington, D. C. -- There are two good drug options for preventing breast cancer in high-risk women, and more women need to take advantage.

     
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