Metformin longevity

Discussion in 'Canada Pharmacy' started by mam, 19-Aug-2019.

  1. Ded Moroz Well-Known Member

    Metformin longevity


    Pterostilbene (terro-still-bean) is a Stilbenoid, an antioxidant produced by plants to protect themselves against viral, bacterial, fungal attack and excessive sunlight much like another in the same family: Resveratrol. Reservatrol has been known for being in the skins of red grapes as an active ingredient, thought to be responsible for the French Paradox : The french have heart healthy and healthier lives than most on their type of diet (as whole, they eat an inflammatory, artery clogging, pro diabetes and pro cancer diet. But thanks to their love of red wine and the Resveratrol it contains, they are not prone to these diseases). Reservatrol has also been identified for other properties, including anti-diabetic, anti-inflammatory, and anti-cancer. Pterostilbene is a very similar molecule to Resveratrol’s, but where Resveratrol has three hydroxyl groups at its extremities, two of them are replaced with methoxy groups in Pterostilbene. This difference makes Pterostilbene far more bioavailable than Resveratrol: It’s more easily absorbed through the stomach lining and cell membranes and stays in one’s system longer, giving it similar, but more powerful effects. 29: A Review of Pterostilbene Antioxidant Activity and Disease Modification. Researchers believe pterostilbene and resveratrol work through same pathways biologically. Oxidative Medicine and Cellular Longevity; Volume 2013 (2013), Article ID 575482, 15 pages 30: Antioxidant effect of trans-resveratrol, pterostilbene, quercetin and their combinations in human erythrocytes in vitro. Because of this, pterostilbene and resveratrol supplements are now being offered by several supplement companies. doi: 10.3389/fphar.2012.00141 28: Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Some researchers in this area, and "life extensionists", "immortalists" or "longevists" (those who wish to achieve longer lives themselves), believe that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition. The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists. The sale of purported anti-aging products such as supplements and hormone replacement is a lucrative global industry. For example, the industry that promotes the use of hormones as a treatment for consumers to slow or reverse the aging process in the US market generated about $50 billion of revenue a year in 2009. During the process of aging, an organism accumulates damage to its macromolecules, cells, tissues, and organs. Specifically, aging is characterized as and thought to be caused by "genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication." The longest documented human lifespan is 122 years, the case of Jeanne Calment who according to records was born in 1875 and died in 1997, whereas the maximum lifespan of a wildtype mouse, commonly used as a model in research on aging, is about three years. Genetic differences between humans and mice that may account for these different aging rates include differences in efficiency of DNA repair, antioxidant defenses, energy metabolism, proteostasis maintenance, and recycling mechanisms such as autophagy.

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    Metformin is widely prescribed to manage blood sugar. to preventing chronic disease, to increasing longevity in otherwise healthy people. Millions of people have taken metformin for centuries for symptoms of. They're trying to lengthen our healthspan, not our lifespan, so that we. The Dark Side Of Metformin A "Longevity Wonder Drug" That Promises to Extend Life For A Nickel A Pop.

    This conference addresses factors that may contribute to healthier lifestyles and outcomes, thereby delaying the onset of age-associated diseases and extending longevity. The focus is to highlight cutting-edge advances in aging research, novel technologies and potential therapeutic interventions. Included are talks on mechanisms of aging in a wide range of established and non-traditional animal models with the key objective to enhance understanding of the basic biology behind experimental and lifestyle manipulations thought to have direct translational application to human aging. The conference will focus on topics not covered at previous Keystone Symposia meetings on aging biology and will specifically examine both the fundamental mechanisms involved in the aging process as well as interventions and potential therapeutics that may delay aging and the onset of age-associated diseases to forge a deeper understanding of the complex, multifactorial aging process. The discussions of novel interventions and/or therapeutics that appear to slow aging processes will, in turn, guide the field toward facilitating extended periods of good health and prolonging lifespan in humans. The meeting will begin on Sunday, April 15 with registration from to and a welcome mixer from to . Conference events conclude on Thursday, April 19 with a closing plenary session from to , followed by dinner and entertainment. We visit IGF-1 and whether there’s a tradeoff between having high or low levels. and I go on a Nerd Safari into the jungle of health, nutrition, fitness, performance, and longevity. We discuss the PPARs (receptor proteins) and genetic polymorphisms. Does Rhonda think there’s any benefit in a NAD booster for health and longevity? Can saunas lower the risk of heart disease, dementia, and all-cause mortality? Subscribe on: APPLE PODCASTS | RSS | GOOGLE | OVERCAST | STITCHER Rhonda is a wealth of knowledge and was the perfect companion to explore several interesting topics in this episode. She puts a great deal of thought and effort into her research, and it really shows in this conversation.

    Metformin longevity

    Keystone Symposia Scientific Conferences on Biomedical., Is Metformin really the world's first anti-aging wonder drug? - One Drop

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  7. Clinical lists 1989 clinical trials mentioning Metformin but only three clinical trials mentioning Metformin and longevity. All three of these are placebo.

    • Metformin reduces all cause mortality and may extend lifespan..
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    I think it appropriate to update my progress with metformin extended release version that is prescribed to me by the VA, taken with 100 mg of the synthetic USDA version of pterostilbene, which is covered by a U. S. government held patent. Last year, I wrote about 10 of the most interesting predictors of longevity. Many of them were subjective, but, as we all know, the objective physiological processes that occur in the human body also predict how long we live. Luckily, we can measure most of them. Some are standard at doctor’s. In recent years, metformin has been shown to extend the lifespan in some animal models. However, whether metformin can suppress human.

     
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    DOSAGE AND ADMINISTRATION Cymbalta should be swallowed whole and should not be chewed or crushed, nor should the capsule be opened and its contents sprinkled on food or mixed with liquids. For some patients, it may be desirable to start at 30 mg once daily for 1 week, to allow patients to adjust to the medication before increasing to 60 mg once daily. Initial Treatment Major Depressive Disorder -- Cymbalta should be administered at a total dose of 40 mg/day (given as 20 mg twice daily) to 60 mg/day (given either once daily or as 30 mg twice daily). While a 120 mg/day dose was shown to be effective, there is no evidence that doses greater than 60 mg/day confer any additional benefits. The safety of doses above 120 mg/day has not been adequately evaluated. Generalized Anxiety Disorder--For most patients, the recommended starting dose for Cymbalta is 60 mg administered once daily. For some patients, it may be desirable to start at 30 mg once daily for 1 week, to allow patients to adjust to the medication before increasing to 60 mg once daily. While a 120 mg once daily dose was shown to be effective, there is no evidence that doses greater than 60 mg/day confer additional benefit. Cymbalta - Uses, Side Effects, Interactions - Duloxetine Australian Prescriber - NPS MedicineWise CYMBALTA Dosage & Rx Info Uses, Side Effects -
     
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