Doxycycline for arthritis

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  1. aldinas Guest

    Doxycycline for arthritis


    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. RA attacks the lining of the joints (synovium), causing swelling that can result in aching and throbbing, and eventually deformity. Listing a study does not mean it has been evaluated by the U. Even though there have been many advances in the treatment of RA, psoriatic arthritis (Ps A), and other inflammatory arthritis, doctors still do not know what causes this inflammation in joints. Rheumatoid arthritis (RA) is an inflammatory form of arthritis that causes joint pain and damage. It is likely that RA occurs as a result of a complex combination of factors, including a person's genes; lifestyle choices, such as smoking and diet; and things in a person's environment, including bacteria or viruses. This study investigates the hypothesis that bacteria living in a person's mouth and/or intestinal tract are responsible, at least in part, for the development of Rheumatoid Arthritis. The investigators believe that by killing those bacteria with antibiotics, they might be able to understand how the immune system works and, maybe, what causes RA. If you would like to participate in this study, we will first ask you several questions regarding the status of your arthritis, the medications you use or have used in the recent past, your social and dietary habits, and your medical and surgical history. Preliminary evidence from experimental animal models has suggested that doxycycline may be effective in preventing or slowing the progression of osteoarthritis (OA), perhaps through its ability to modulate the activity of cartilage-degrading matrix metalloproteases (MMPs). Despite this encouraging animal evidence, no studies have investigated doxycycline in humans with, or at risk for, OA. Here, Brandt et al (Arthritis Rheum 2005;52(7): 2015) examine the potential for doxycycline to slow the progression of unilateral knee OA in obese women. Obese women 45 to 64 years of age with radiographic evidence of moderate (K/L grade 2 or 3) unilateral knee OA were randomized to receive doxycycline 100 mg twice daily or matched placebo for 30 months. Adherence was assessed via electronic monitors affixed to the study drug containers. The primary outcome measure was the change in joint space width (JSW) in the medial tibiofemoral compartment for both the index and contralateral knees. JSW was measured via fluoroscopically positioned semi-flexed radiographs of the knees, obtained at baseline, 16 and 30 months.

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    Patients with rheumatoid arthritis RA meeting inclusion criteria, randomized to receive no antibiotic treatment for comparison with Doxycycline- and. Oct 18, 2011. Minocycline and doxycycline therapy in community patients with rheumatoid arthritis prescribing patterns, patient-level determinants of use. Persistent arthritis after clearance of the infection is most likely related to autoimmunity and is moreTreatment for 14 days is recommended range, 10-21 d for doxycycline and 14-21 d for amoxicillin.

    Researchers compared the use of doxycycline to placebo, after enrolling more than 400 obese women with knee arthritis as study participants. The study participants were randomized into two groups, receiving either 100 mg of doxycycline twice daily or a placebo for up to 2.5 years. Researchers analyzed the impact of doxycycline on the joint space of the affected knee. Following 16 months of treatment, results indicated that the average loss of joint space in the affected knee was 40% less among participants taking doxycycline than those who took a placebo. At the end of the two and a half year period, the loss of joint space was 33% less in the group who took doxycyline than in the placebo group. Doxycycline was also associated with less patient-reported increases in knee pain. Researchers acknowledged, though, that the average level of pain was low in both groups. RA is a chronic inflammatory disease that often leads to joint damage, deformity, and dysfunction. The treatment of this disease has been hampered by an incomplete understanding of its pathogenesis and the absence of identifiable etiologic factors. The etiology of RA has long been suspected to be triggered by infection with bacteria, especially mycoplasma. One approach to investigating the possible role of bacterial infection in RA is empiric treatment with antibiotics. Recent studies of patients with RA of relatively long duration suggest that oral minocycline therapy modestly improves the signs and symptoms of arthritis. Minocycline, while an effective broad spectrum anti-microbial agent, can also suppress collagenase, a degradative enzyme prominent in the pathogenesis of joint destruction. Two important questions remain concerning this approach: 1-Can the clinical efficacy of minocycline in RA be improved by intensifying the antibiotic regimen and/or selectively targeting early disease?

    Doxycycline for arthritis

    Is your arthritis actually caused by bacteria? - NYU Langone Health, Minocycline and doxycycline therapy in community patients with.

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  5. Minocycline and doxycycline are safe and moderately effective disease-modifying anti-rheumatic drugs DMARDs in the treatment of early, DMARD-naïve rheumatoid arthritis RA, although little is known.

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    Can antibiotics really help in the treatment of rheumatoid arthritis? Find out what research shows about antibiotics possibly helping control the disease. Jan 30, 2006. To compare the efficacy of doxycycline plus methotrexate MTX versus MTX alone in the treatment of early seropositive rheumatoid arthritis. OBJECTIVE To assess the efficacy and safety of doxycycline as a disease modifying anti-rheumatic drug DMARD in rheumatoid arthritis RA and compare it.

     
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