Metformin and aging

Discussion in 'Canada Drug Pharmacy' started by Optimism.ru, 01-Jan-2020.

  1. beliy1973 Guest

    Metformin and aging


    Long-term treatment with the type 2 diabetes drug metformin improves health and longevity of male mice when started at middle age, reports an international team of scientists led by researchers at the National Institute on Aging (NIA), part of the National Institutes Health. The study, which tested two doses of the drug in the male mice, found the higher dose to be toxic in the animals. Scientists emphasized that considerably more research is needed before the implications of metformin for healthy aging are known for humans. D., of the NIA’s Intramural Research Program, was published in the July 30, 2013 issue of Nature Communications. “It is exciting to discover that a drug already known to be safe and effective in humans might be further studied for a possible, alternate use for healthy aging.” Prescribed since the 1960s to treat type 2 diabetes, metformin is known to enhance insulin sensitivity, prompt sugar to be converted to energy, and prevent sugar build up in the liver. “There is increasing interest in exploring how drugs for one use might be repurposed for another,” notes Richard J. It also reduces risk of health issues associated with metabolic syndrome, a condition characterized by an increased chance for heart disease and stroke, as well as type 2 diabetes. “Aging is a driving force behind metabolic syndrome and diabetes. Given that metformin is clinically proven to alleviate symptoms of these conditions, and reduce risk of cancer, we thought perhaps it was a good candidate to study for its broader effects on health and lifespan,” said de Cabo. Specifically, de Cabo’s research focuses on testing compounds that might mimic benefits of calorie restriction, as shown in some animal models. Some exciting research from the University of Montreal has found that the drug metformin, commonly prescribed for diabetes and polycystic ovary syndrome (PCOS), has the potential to slow aging and fight cancer. The study, published in , found that metformin reduces the body's production of inflammatory cytokines, which accelerate aging. Metformin is the generic name for an oral drug that was approved by the FDA in 1994 to lower blood sugar. Brand names include Glucophage and Glucophage XR (Bristol-Myers Squibb), Fortamet (Shionogi), Glumetza and Glumetza XR (Santarus), and Riomet (Ranbaxy). Metformin was later found to stimulate ovulation, regulate periods, and increase fertility in women with PCOS and is now commonly prescribed for women whose PCOS hasn't responded to hormonal treatment alone. Found: New Potential to Slow Aging, and Slow Tumor Growth Cytokines have an important function in the body, activating the immune system to fight infection. But because they work by an inflammatory process, when they're overproduced they put the body into a state of chronic inflammation, which causes cells to age faster.

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    Metformin Anti Aging - Anti Aging Training Courses Laser Vaginal Rejuvenation Arizona Iowa Skin Clinic West Des Moines Metformin And Anti Aging - Anti Wrinkle Treatments At Home Metformin And Anti Aging Removal Of Perianal Skin Tags Beverly Hills Skin Care Products Reviews Metformin Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists AHFS DI.

    Watch the TEDMED talk by AFAR Deputy Scientific Director Nir Barzilai, Can We Grow Older Without Getting Sicker? The entire National Geographic special, Breakthrough: The Age of Aging, spotlighting TAME and featuring AFAR experts, can be purchased on i Tunes or Amazon. Years ago I was excited about the thought of metformin being part of anti aging protocol. The latest research that I have read shows that metformin could increase chance of dementia in healthy older adults. Reply I take some supplements for their anti-aging benefits, but I would not take metformin, at least not until a lot more study is done on its benefits/drawbacks for healthy people (and those studies are not likely to be done anytime soon, as John says). I had a little test drive with metformin, took 1000mg and increased to 2000mg a day for almost 3 weeks. There are studies out there that found that Vitamin B12 deficiency is very common among metformin users, which is disturbing: https://gov/pubmed/21940283 Lots of other potential negative side effects also. My appetite went down, it felt like my stomach was fuller after meals and that my digestion was slower kind of how you feel after a heavy meal. Energy was lower when walking around and in the gym, which coincides with the lower VO2 max. I’ve tried metformin too, might have made me less hungry. The fact that all these rats studies are made with the equivalent diet of very unhealthy people makes me look at most studies with more skepticism. But I’ve only taken 500 mg at a time, and not daily. From the study on exercise and metformin, seems like one might get some benefit from metformin by taking it only sporadically and not on exercise days.

    Metformin and aging

    Metformin The Anti-Aging Miracle Drug - Jeffrey Dach MD, Metformin And Anti Aging -

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  6. Long-term treatment with the type 2 diabetes drug metformin improves health and longevity of male mice when started at middle age, reports an international.

    • NIH researchers find diabetes drug extends health and lifespan in..
    • Metformin Hydrochloride Monograph for.
    • Metformin - Wikipedia.

    Metformin ist ein Arzneistoff aus der Gruppe der Biguanide, der in der Regel bei nicht insulinabhängiger Zuckerkrankheit Diabetes mellitus Typ 2 und insbesondere bei leichtem Übergewicht Präadipositas und krankhaftem Übergewicht eingesetzt wird. Aging in humans is a well-established primary risk factor for many disabling diseases and conditions, among them diabetes, cardiovascular disease, Alzheimer's disease and cancer. What is the TAME Trial? Targeting Aging with Metformin TAME is a novel clinical trial, that will test whether the drug metformin, a widely-used treatment for type 2.

     
  7. seregarulez New Member

    β-lactamase−producing strains of Haemophilus influenzae and Moraxella catarrhalis Mild to moderate: 500/125 mg PO q12hr or 250/125 mg PO q8hr for 10 days Severe: 875/125 mg PO q12hr or 500/125 mg PO q8hr or 2000 mg (2 extended-release tabs) PO q12hr for 7-10 days Take with meals to avoid GI upset Take suspension at start of meal to enhance absorption Dysphagia: May substitute 250 mg/5 m L suspension for 500/125 mg tablet; may substitute 200 mg/5 m L or 400 mg/5 m L suspension for 875/125 mg tablet Because of the different amoxicillin-to-clavulanate ratios in the 250-mg tablet (amoxicillin 250 mg, clavulanate125 mg) and the 250-mg chewable tablet (amoxicillin 250 mg, clavulanate 62.5 mg), the 250-mg tablet should not be used if the pediatric patient weighs Hypersensitivity reactions Anaphylaxis Anemia Thrombocytopenia Leukopenia Agranulocytosis Hepatoxicity AST/ALT elevation Pseudomembranous colitis Serum sickness Abdominal discomfort Cholestatic jaundice Flatulence Allergy to cephalosporins, carbapenems Different tablets are not interchangeable, because ratios of amoxicillin to clavulanate are different Extended release tablets not for use in renal impairment (Cr Cl Amoxicillin binds to penicillin-binding proteins, thus inhibiting final transpeptidation step of peptidoglycan synthesis in bacterial cell walls; addition of clavulanate inhibits beta-lactamase-producing bacteria, allowing amoxicillin extended spectrum of action It is a semisynthetic antibiotic with a broad spectrum of bactericidal activity, covering both gram-negative and gram-positive microorganisms Not effective against Mycoplasma and Legionella spp Peak plasma time: 2 hr (amoxicillin); 1.1 hr (clavulanic acid) Peak concentration: 8-22 mcg/m L (amoxicillin); 0.8-2.6 mcg/m L (clavulanic acid) AUC: 40-80 mcg•hr/m L (amoxicillin); 2-6 mcg•hr/m L (clavulanic acid) The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Amoxicillin-Potassium Clavulanate Oral Uses, Side Effects - WebMD Augmentin Amoxicillin Clavulanate Side Effects, Interactions. Amoxicillin/clavulanic acid - Wikipedia
     
  8. Sidney Moderator

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