Tamoxifen has been used for several years to treat breast cancer which is hormone receptor-positive. This is because of its ability to competitively block estrogen binding to estrogen receptors, which stimulates breast cancer cell growth. As a selective estrogen receptor modulator (SERM), however, it not only antagonizes the actions of estrogen at its receptor by blocking its binding, but mimics other actions through its own binding to the estrogen receptor. This is common to most SERMs, including raloxifene and toremifene, all of which act as estrogen antagonists in some organs or tissues, such as the breast, but as partial estrogen agonists in other target tissues, like the uterus and bone. Tamoxifen thus promotes uterine endometrial hyperplasia as well as bone growth, but restricts the growth of breast tissue. The binding of tamoxifen to estrogen receptors has a profound effect on normal feedback processes. It induces the hypothalamus to sense a falsely high estrogen level, resulting in cessation of ovarian stimulation. Tamoxifen-induced estrogen deprivation causes side effects such as hot flashes in 35% of patients. Anastrozole has become popular for the treatment and prevention of breast cancer. It’s been found to be more effective than the former leading drug for breast cancer treatment, tamoxifen. Unfortunately, more research on its side effects reveals that joint issues are a particular concern with this drug. Many postmenopausal women using anastrozole, known as Arimidex, experience an increased risk of experiencing bone and joint pain. Anastrozole does, in fact, list joint pain and bone loss as potential side effects. was conducted to determine the severity of arthritic pain associated with anastrozole. It studied 9366 postmenopausal women using either anastrozole or tamoxifen or a combination of both to treat their breast cancer. Fluconazole oral dose Where to buy bactrim Where can i buy xenical in usa Tadalafil reviews Background/Purpose The well-known positive effect of pregnancy on improving Rheumatoid Arthritis RA disease activity suggests that hormonal changes may play a role in disease pathogenesis and raises a concern that anti-estrogen therapy AET including Aromatase Inhibitors AI and selective estrogen receptor modulators SERMs may have an adverse effect on RA. I think for arthritis, tamoxifen is the lesser of two evils. you've heard what I said about the emotional side. but that stopped after couple of. Aromatase inhibitors. Aromatase inhibitors are widely used to treat estrogen receptor-positive breast cancer in postmenopausal women. Joint pain is a common side effect 1, 2. In contrast, the onset of rheumatoid arthritis RA seems exceedingly rare. If you have hormone receptor-positive breast cancer, hormone therapy with tamoxifen and/or an aromatase inhibitor (anastrozole, letrozole or exemestane) is a key part of your treatment. Aromatase inhibitors are only used to treat postmenopausal women (and some premenopausal women also getting ovarian suppression). Joint pain (arthralgia) and muscle pain (myalgia) are common side effects of aromatase inhibitors [85-87]. Compared to chemotherapy, aromatase inhibitors have fewer side effects. The pain may be in the hands and wrists, feet and ankles, knees, back or other parts of the body. About 46 percent of women taking aromatase inhibitors have joint pain and about 15 percent have muscle pain [85-87]. Joint and muscle pain can mimic carpal tunnel syndrome. And, in rare cases, aromatase inhibitors can cause carpal tunnel syndrome . Although aromatase inhibitors can cause joint and muscle pain, they don’t cause permanent joint or muscle damage. Tamoxifen belongs to the group of cancer-fighting medications known as antineoplastics, and specifically to the type of antineoplastics known as antiestrogens. It is used in combination with other medications to treat early breast cancer. Tamoxifen fights certain types of breast cancer, called hormone responsive or estrogen receptor positive breast cancer, by blocking the effects of the hormone estrogen in the body. This prevents the growth of the types of breast cancer cells that require estrogen for growth and survival. It is also used to treat breast cancer that is advanced or has spread to other parts of the body. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. Tamoxifen arthritis Who have Gout with Tamoxifen citrate - from FDA reports., Tamoxifen and joint pain Cancer Chat Where to buy viagra bodybuilding Some treatments can increase your risk of bone thinning or cause joint problems. Looking after your bones can help. Effects on the bones and joints - Information and support - Macmillan.. Rheumatoid arthritis and aromatase inhibitors - ScienceDirect. Influence of aromatase inhibitors therapy on the. - RMD Open. Tamoxifen is used to treat breast cancer that has spread to other parts of the body metastatic breast cancer, to treat breast cancer in certain patients after surgery and radiation therapy, and to reduce the chances of breast cancer in high-risk patients. This medication can block the growth of breast cancer. Sep 24, 2013. I want to then everyone on this thread. I've been on tamoxifen for 4 years and flet that I was being a whimp still struggling with the side effects. Side effects due to the estrogen agonist activity of tamoxifen. Tamoxifen also causes side effects due to its modest estrogen-like activity. These include endometrial proliferation, endometrial hyperplasia, endometrial polyp formation, invasive endometrial cancer, uterine sarcoma, venous thromboembolism and its complications, such as stroke.