Thrush is a fungal infection and is treated with anti-fungal medications. These are only available with a doctor's prescription; they are not available over-the-counter. Oral thrush (also called oral candidiasis) -- is a condition in which the fungus candida accumulates on the lining of your mouth. only applied to the part of body that is affected) or systemic (acting on the whole body). Candida is a normal organism in your mouth, but sometimes it can overgrow and cause symptoms. A 'troche' or "lozenge" that dissolves in your mouth is a topical treatment. A liquid that you swish in your mouth and then swallow is another topical treatment. Health care providers usually prefer to give a topical treatment first. It provides the medication exactly where it is needed and is less likely to cause side-effects. Diflucan (fluconazole) is a member of the azole antifungals drug class and is commonly used for Blastomycosis, Bone Marrow Transplantation, Candida Urinary Tract Infection, and others. 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