Misoprostol is a synthetically derived prostaglandin E1 analog which is originally used to treat gastric ulcers but is now widely used for the termination of unintended pregnancies. It causes uterine contractions and opening of the cervix, therefore, aids in the expulsion of the products of conception inside the uterus. The last dose of the day should be taken at bedtime. Misoprostol (Cytotec) is used for reducing the risk of stomach ulcers in certain patients who take nonsteroidal anti-inflammatory drugs (NSAIDs). It works by reducing the amount of acid released by the stomach and protecting the stomach lining, which helps to reduce the risk of stomach ulcers. Taking Cytotec after meals and at bedtime may decrease the risk of diarrhea. Do no take an antacid that has magnecium in it within 1 hour before or 2 hours after you take Cytotec. If you miss a dose of Cytotec, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Ask your health care provider any questions you may have about how to use Cytotec. Concurrent long-term corticosteroid or anticoagulant therapy. Serious and sometimes fatal infections or bleeding. Mifepristone also known as RU-486 is a synthetically produced antiprogesterone agent which blocks the progesterone hormone during the early stage of pregnancy. Nausea, weakness, fever/chills, vomiting, headache, diarrhea, dizziness; uterine bleeding (may be prolonged or severe), cramping; rare: serious bacterial infections, sepsis (may be fatal). Applicants shall follow this procedure (for family members having not yet reached 18 years of Age, the Application form must be signed by a Parent o by a person having the legal custody): An APPLICATION FORM (with the Official Statement) must be duly compiled and submitted via the Official CISRI website together with a scanned passport-size photo JPEG Format (300 dpi), 3,5 cm (width) x 4,5 cm ( height) Alternatively it may be printed out and sent to CISRI Secretariat by post, together with a passport size-photo 3,5 cm (width) x 4,5 cm ( height) The Safe-conduct is renewable every five years by sending back the Safe-conduct to the CISRI Organization, together with a renewal form and the procedure can be repeated with no temporal limits, but every fifteen years the Safe-conduct booklet must be re-issued with an updated photo. 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